Penectomy for self-neglected opportunistic carcinoma: a large primary urogenital squamous cell carcinoma as initial manifestation of HIV-AIDS

Reyes, Antonio Jose; Ramcharan, Kanterpersad; Goetz, Lester; Aboh, Samuel

doi:10.1136/bcr-2016-217040

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…The lack of deep knowledge about the role of lymph node dissection in penile cancer is due also to clinical heterogeneity among published clinical studies. Moreover, the time between the glans lesion appearance and the first urological evaluation ranges from a few days to one or two years, as reported by some case reports [26,27]. In these cases, the delayed diagnosis is due to the significant impact of penile cancer on the patient's self-image and self-esteem.…”

Section: Limitationsmentioning

confidence: 99%

Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better?

Cai,

Capece,

Zorzi

et al. 2023

Uro

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Background: Management of penile cancer patients has its grey zones. In particular, no strong evidence or recommendations exist regarding the timing of prophylactic lymphadenectomy. Here, we aim to review the impact that the timing of inguinal and pelvic prophylactic lymph node dissection has on patient outcome. Methods: All relevant databases were searched following the preferred reporting items for systematic reviews and meta-analysis guidelines. A narrative review of indications for lymph node dissection and pathological considerations precede a systematic review of the impact of prophylactic lymph node dissection timing on prognosis. The primary endpoint is disease-free and overall survival in patients undergoing early or late lymph node dissection after penile cancer diagnosis. Results: Four clinical trials, all focusing on the role of inguinal lymph node dissection, are included. Despite the lack of randomized and controlled trials, this review suggests that lymph node dissection should be performed as soon as possible after diagnosis, with 3 months as a realistic cut-off. Conclusions: Survival of penile cancer patients is strictly related to the timing of prophylactic pelvic lymph node dissection. All patients at high risk of nodal metastasis should be offered lymph node dissection within three months of diagnosis, until new predicting tools are validated.

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Section: Limitationsmentioning

confidence: 99%

Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better?

Cai,

Capece,

Zorzi

et al. 2023

Uro

View full text Add to dashboard Cite

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Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner the Better?

Cai,

Capece,

Zorzi

et al. 2023

Preprint

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Background: The management of penile cancer patients has some grey zones, one of them being the timing of prophylactic pelvic lymph node dissection. Here, we review the impact of timing of prophylactic inguinal and pelvic lymph node dissection on patients’ outcome. Methods: Relevant databases were searched according to recommendations by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Before the systematic review we present a narrative review on the indications for lymph node dissection and the impact of pathological anatomical considerations on the timing of prophylactic lymph node dissection and patients’ outcome. The primary research questions were disease-free and overall survival rate in patients who underwent early or late lymph node dissection after penile cancer diagnosis. Results: Four clinical trials were included in the systematic review. Conclusions: The survival rate of patients with penile cancer is strictly associated with the timing of prophylactic pelvic lymph node dissection. Even though there are no randomized controlled trials we conclude that there is evidence for a strong recommendation that lymph node dissection should be performed as soon as possible after diagnosis with3 months as a realistic cut-off time between early and late. According to the present evidence base, lymph node dissection should be offered the sooner the better to all patients at high risk of lymph node metastasis.

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Penectomy for self-neglected opportunistic carcinoma: a large primary urogenital squamous cell carcinoma as initial manifestation of HIV-AIDS

Cited by 2 publications

References 2 publications

Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better?

Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better?

Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner the Better?

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