Pencil beam scanned protons for the treatment of patients with Ewing sarcoma

Weber, Damien Charles; Murray, Fritz Ruprecht; Correia, Dora; Bolsi, Alessandra; Frei-Welte, M.; Pica, Alessia; Lomax, Anthony; Schneider, R.; Bachtiary, Barbara

doi:10.1002/pbc.26688

Cited by 16 publications

(5 citation statements)

References 52 publications

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“…Most commonly reported margins types were GTV-CTV and CTV-PTV margins for thoracic [44, (Fig. 2A), abdominal [15,18,30,41,45,[50][51][52][53][54][55][56]60,[62][63][64]66,70,73,74,[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] (Fig. 2B), spinal [43,46,48,63,82, (Fig.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Pediatric radiotherapy for thoracic and abdominal targets: Organ motion, reported margin sizes, and delineation variations – A systematic review

Meijer¹,

Dijk²,

Huijskens³

et al. 2022

Radiotherapy and Oncology

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Section: Resultsmentioning

confidence: 99%

“…2A), abdominal [15,18,30,41,45,[50][51][52][53][54][55][56]60,[62][63][64]66,70,73,74,[76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] (Fig. 2B), spinal [43,46,48,63,82, (Fig. 2C) and pelvic treatment sites [55,58,85,120,121] (Fig.…”

Section: Resultsmentioning

confidence: 99%

Pediatric radiotherapy for thoracic and abdominal targets: Organ motion, reported margin sizes, and delineation variations – A systematic review

Meijer¹,

Dijk²,

Huijskens³

et al. 2022

Radiotherapy and Oncology

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“…The delivery of PT has been previously described 11 . For the 23 patients of our cohort, the median delivered radiation dose was 55.8 Gy (RBE) (range 45–69.6).…”

Section: Methodsmentioning

confidence: 99%

“…To the best of our knowledge, this is the first report of QoL outcomes for EWS patients treated with pencil‐beam‐scanning PT only. The clinical results for this cohort of EWS patients have been recently published by our group 11 …”

Section: Introductionmentioning

confidence: 99%

Quality‐of‐life evaluations in children and adolescents with Ewing sarcoma treated with pencil‐beam‐scanning proton therapy

Weber

Beer

Kliebsch

et al. 2022

Pediatric Blood & Cancer

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Background: With improved survival rates for children with cancer, quality-of-life (QoL) issues have increasingly become the focus of attention. We report the QoL of children with Ewing sarcoma (EWS) treated with pencil-beam-scanning proton therapy (PT). Methods:A PEDQOL (QoL questionnaire for children 4-18 years) self/proxy questionnaire was used to prospectively assess the QoL of 23 children <18 years with EWS treated with PT. This questionnaire evaluates eight different domains. Children (selfrating) and parents (proxy-rating) filled out the questionnaire at the start of PT (E1), 2 months after treatment (E2), and thereafter once yearly (E≥3).Results: Compared with healthy controls, parents rated the QoL of their children at E1 significantly worse in all but two (cognition and social functioning-family) domains.At E4, significant differences between the two groups only remained in three of eight domains. At E1, children self-rated their QoL significantly worse in the domain Physical functioning (p = .004) and significantly better in the domain Body image (p = .044) compared to healthy controls, whereas no significant differences were observed at E4.For the longitudinal comparison E1 versus E4, according to parents, Emotional functioning, Cognition and Social functioning-peers were slightly decreased 2 years after PT. The children rated Emotional functioning and Body image poorly 2 years after PT. Conclusions:Children with EWS usually recovered seemingly well to normal QoL levels 2 years after the end of PT. They tended to rate their QoL substantially higher

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“…9,10 Within the last couple of decades, proton therapy availability has increased substantially while the therapy itself has evolved from 3D conformal proton therapy (3DCPT) 11 using double scattering technique or uniform scanning technique to pencil beam scanning (PBS) using intensity-modulated proton therapy (IMPT) technique. 12 In this study, dosimetric comparisons were made between photon intensity-modulated radiotherapy (IMRT), 3DCPT, and IMPT plans for six pediatric patients with posterior chest wall Ewing sarcomas. Total integrated dose was also calculated for all the plans as a potential indication of secondary cancer possibilities.…”

mentioning

confidence: 99%

Impact of different treatment techniques for pediatric Ewing sarcoma of the chest wall: IMRT, 3DCPT, and IMPT with/without beam aperture

Indelicato

Vega

et al. 2020

J Applied Clin Med Phys

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Purpose: To evaluate the dosimetric differences between photon intensity-modulated radiation therapy (IMRT) plans, 3D conformal proton therapy (3DCPT), and intensity-modulated proton therapy (IMPT) plans and to investigate the dosimetric impact of different beam spot size and beam apertures in IMPT for pediatric Ewing sarcoma of the chest wall. Methods and Materials: Six proton pediatric patients with Ewing sarcoma in the upper, middle, and lower thoracic spine regions as well as upper lumbar spine region were treated with 3DCPT and retrospectively planned with photon IMRT and IMPT nozzles of different beam spot sizes with/without beam apertures. The plan dose distributions were compared both on target conformity and homogeneity, and on organs-at-risk (OARs) sparing using QUANTEC metrics of the lung, heart, liver, and kidney. The total integral doses of healthy tissue of all plans were also evaluated. Results: Target conformity and homogeneity indices are generally better for the IMPT plans with beam aperture. Doses to the lung, heart, and liver for all patients are substantially lower with the 3DPT and IMPT plans than those of IMRT plans. In the IMPT plans with large spot without beam aperture, some OAR doses are higher than those of 3DCPT plans. The integral dose of each photon IMRT plan ranged from 2 to 4.3 times of proton plans. Conclusion: Compared to IMRT, proton therapy delivers significant lower dose to almost all OARs and much lower healthy tissue integral dose. Compared to 3DCPT, IMPT with small beam spot size or using beam aperture has better dose conformity to the target.

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Pencil beam scanned protons for the treatment of patients with Ewing sarcoma

Abstract: These preliminary data suggest that the outcomes of children and AYA with EWS are good and PT was well tolerated with few late adverse events. The local and distant tumor control for older patients with large pre-PT tumor volumes remains problematic.

Cited by 16 publications

References 52 publications

Pediatric radiotherapy for thoracic and abdominal targets: Organ motion, reported margin sizes, and delineation variations – A systematic review

Pediatric radiotherapy for thoracic and abdominal targets: Organ motion, reported margin sizes, and delineation variations – A systematic review

Quality‐of‐life evaluations in children and adolescents with Ewing sarcoma treated with pencil‐beam‐scanning proton therapy

Impact of different treatment techniques for pediatric Ewing sarcoma of the chest wall: IMRT, 3DCPT, and IMPT with/without beam aperture

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