Pencemaran Akrilamida pada Lingkungan dan Dampak Negatif serta Mekanismenya pada Terjadinya Penyakit Kanker: Review

Abstract

Acrylamide is a chemical commonly used for water treatment 45%, oil drilling 20%, pulp and paper 20%, mining 10%, and other 5%. Acrylamide is naturally formed from starchy foods/carbohydrates heated at a temperature of 120 C. Acrylamide contamination can be through surface water or ground air, through air channels that flow into wells, rivers, to the sea. Several studies have reported an increased risk of kidney disorders, endometrial cancer, and ovarian cancerdue to exposure to acrylamide. Acrylamide can cause ovarian cancer through its effects on sex hormones. Research shows that glycidamide mutations are found in one-third of the approximately 1,600 tumor genomes corresponding to 19 human tumor types from 14 organs. There is an unexpected extensive contribution of acrylamide-associated mutagenesis in human cancer. Enriched presence of glycidamide was observed in lung cancers (88%), liver tumors (73%), kidney (above 70%), bile ducts (57%), cervical (50%), and to a lesser extent, breast cancer. additional cancer.