Penalized logistic regression for classification and feature selection with its application to detection of two official species of Ganoderma

Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects

“…11,12 G. lucidum and its closely related species G. sinense are suggested be used interchangeably as Lingzhi according to Chinese Pharmacopoeia. 2,3,13,14 Chemical investigations on the two species of Ganoderma based on multiple analytic technologies or chemical separation have been carried out, and triterpenoids and polysaccharides were determined as the major constituents 13,15−22 of G. lucidum, while studies on G. sinense are relatively few, showing the presence of meroterpenoids, steroids, alkaloids, triterpenoids, and polysaccharides. 13,23−28 Comparing the chemical constituents from two official species of Ganoderma genus demonstrated the significant difference on type and content of triterpenoids by high performance liquid chromatography coupled with photodiode array (HPLC-PDA) and high performance liquid chromatography−mass spectrometry (LC−MS) analyses, with about 10 times higher in G. lucidum than G. sinense, and lack of common triterpenes in G. sinense.…”

“…G. lucidum and its closely related species G. sinense are suggested be used interchangeably as Lingzhi according to Chinese Pharmacopoeia. ,,, Chemical investigations on the two species of Ganoderma based on multiple analytic technologies or chemical separation have been carried out, and triterpenoids and polysaccharides were determined as the major constituents ,− of G. lucidum , while studies on G. sinense are relatively few, showing the presence of meroterpenoids, steroids, alkaloids, triterpenoids, and polysaccharides. ,− Comparing the chemical constituents from two official species of Ganoderma genus demonstrated the significant difference on type and content of triterpenoids by high performance liquid chromatography coupled with photodiode array (HPLC-PDA) and high performance liquid chromatography–mass spectrometry (LC–MS) analyses, with about 10 times higher in G. lucidum than G. sinense , and lack of common triterpenes in G. sinense . , While the similar chemical features of polysaccharides between both species were observed, , they also showed similar antitumor and immunomodulating activities . Although polysaccharides as the active principles could explain to some extent the official use of both species as Lingzhi, the influence of numerous small-molecular constituents and their different bioactivities in both species remains to be further investigated and provides a deeper explanation for their exchangeable usage in China.…”

High‐dimensional spectral data classification with nonparametric feature screening

“…There are mainly four chosen regions in the two screening methods, including the 1756‐1668, 1468‐1456, 1310‐1296, and 1176‐1172 (nm). These ATR‐FTIR spectra regions represent the C═O carbonyl stretching of saturated aliphatic esters, C−O stretching of carboxylic acids, and so on.…”

“…Ganoderma (lingzhi) classification data were previously analysed in Zhu et al 34 According to their work, the two species differ in levels of effective chemical components, especially the triterpenoids. 34 This dataset consists of 60 Ganoderma lucidum and 60 Ganoderma sinense samples. For each sample, six spectra respectively were recorded from the top surface and bottom surface.…”

Discovering significant topics from legal decisions with selective inference

“…Penalized regressions are one standard countermeasure to both problems [48,49,[52][53][54]. In bioinformatics and chemometrics, LASSO regressions have been successfully deployed in studies involving large feature matrices and rare events [55,56]. Third, the LASSO lets us exploit emerging methods for selective inference.…”