Pemphigus vulgaris presenting in a radiation portal

Robbins, Amber; Lazarova, Zelmira; Janson, Marleen M.; Fairley, Janet A.

doi:10.1016/j.jaad.2006.10.956

Cited by 26 publications

(21 citation statements)

References 16 publications

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“…The term "radiation port dermatophytosis" was introduced to describe the development of tinea corporis at the site of irradiated skin. 28 A variety of immune disorders may also have a location confined to irradiated areas, including lichen planus, 29 lichen sclerosus et atrophicus, 30 morphea, 31 erythema multiforme, 32 pemphigus, 33 and bullous pemphigoid. 34,35 A striking example is the report of pemphigus vulgaris with cutaneous lesions precisely limited to the skin within the therapeutic radiation portal, 33 which could be labeled "radiation port pemphigus."…”

Section: Immunologic Response To Burn Injurymentioning

confidence: 99%

Radiation dermatitis, burns, and recall phenomena: Meaningful instances of immunocompromised district

Ruocco

Maio

Caccavale

et al. 2014

Clinics in Dermatology

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Section: Immunologic Response To Burn Injurymentioning

confidence: 99%

Radiation dermatitis, burns, and recall phenomena: Meaningful instances of immunocompromised district

Ruocco

Maio

Caccavale

et al. 2014

Clinics in Dermatology

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“…One of the clearest examples of immune disorders occurring at the site of radiation is a recent report of pemphigus vulgaris with cutaneous involvement limited precisely to the skin within the therapeutic radiation portal. 79 Conversely, irradiated areas can paradoxically be spared by widespread lesions of a concomitant skin disorder (e.g. drug rash, 80 psoriasis 81 ), thus featuring reverse köbnerization (Renbök phenomenon).…”

Section: Physical Injuries (Ionizing or Uv Radiation Burns Traumas)mentioning

confidence: 99%

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Ruocco¹,

Brunetti

Puca

et al. 2009

Acad Dermatol Venereol

206

275

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Systemic immunodeficiency is known to facilitate the onset of opportunistic infections, tumours and immune disorders in any district of the body. There are clinical events, such as chronic lymphoedema, herpetic infections, vaccinations and heterogeneous physical injuries which can selectively damage and immunologically mark the cutaneous district they act upon. After the causing event has disappeared, the affected district may appear clinically normal, but its immune behaviour is often compromised forever. An immunocompromised district becomes a site which is particularly susceptible to subsequent outbreaks of opportunistic infections, tumours and immune disorders confined to the district itself. In this review, there is an ample case-report collection of opportunistic disorders (infectious, neoplastic, immune) which appeared in immunocompromised districts. The cases have been grouped according to the clinical settings responsible for the local immune imbalance: regional chronic lymphoedema; herpes-infected sites, which feature the well-known Wolf's isotopic response; and otherwise damaged areas, comprising sites of vaccination, ionizing or UV radiation, thermal burns and traumas. Whatever the immunocompromising factor, a common denominator which facilitates the occurrence of tumours, infections and dysimmune reactions in an immunocompromised district may reside in locally hampered lymph drainage and/or locally altered neuromediator signalling. In fact, any obstacle to the normal trafficking of immunocompetent cells through lymphatic channels or any interference with the signals that the neuropeptides and neurotransmitters released by peripheral nerves send to cell membrane receptors of immunocompetent cells, can significantly alter the local immune response, thus paving the way for heterogeneous opportunistic disorders in the immunocompromised district.

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“…We found less than 20 cases of RIP reported in the literature. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Cases that were, probably or possibly, paraneoplastic or aggravated by radiotherapy were not retained for our study eventhough they were previously published or reported as RIP (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy‐induced pemphigus vulgaris with autoantibodies targeting a 110 kDa epidermal antigen

Badri

Hammami

Lachkham³

et al. 2011

Int J Dermatology

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Our patient showed some distinctive findings never reported previously in RIP: a histological focal keratinocyte necrosis, and the presence of autoantibodies reacting with a 110 kDa keratinocytic protein in immunoblot analysis. Because of a different prognosis, it is important to differentiate RIP and paraneoplastic pemphigus (PNP), although cases of ionizing radiation-induced PNP had also been described. As in our patient, RIP seems to respond well to systemic corticosteroids and immunosuppressive therapy, which induce remission within a few months.

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Pemphigus vulgaris presenting in a radiation portal

Cited by 26 publications

References 16 publications

Radiation dermatitis, burns, and recall phenomena: Meaningful instances of immunocompromised district

Radiation dermatitis, burns, and recall phenomena: Meaningful instances of immunocompromised district

The immunocompromised district: a unifying concept for lymphoedematous, herpes‐infected and otherwise damaged sites

Radiotherapy‐induced pemphigus vulgaris with autoantibodies targeting a 110 kDa epidermal antigen

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