Pemphigus vulgaris: Incidence in Jews of different ethnic groups, according to age, sex, and initial lesion

Pisanti, Simona; Sharav, Yair; Kaufman, Elinore J.; Posner, Ludwg

doi:10.1016/0030-4220(74)90365-x

Cited by 210 publications

(150 citation statements)

References 4 publications

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“…The existing therapies do not allow one to reliably control acute PV without the systemic corticosteroid prednisone, which, although lifesaving, causes serious adverse events, including death, because of the need for its high dose (e.g., 1-2 mg/kg/day) and prolonged (e.g., ϳ18 months) usage to achieve disease control (1,2). Although the incidence of PV is only 1-16 per million population per year (36,37), this disease represents a significant burden to health care professionals and the health care system because of the hazardous side effects of conventional immunosuppressive therapy requiring prolonged and frequent hospitalizations and high costs of modern treatment regimens (38). By identifying the dose-dependent effect, one The drugs had no effect on control cells (not shown).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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Background: Previous studies suggested that mitochondrial antibodies contribute to pemphigus vulgaris (PV). Results: PV sera elicited mitochondrial damage, and mitochondria-protecting drugs exhibited protective effect in cell culture and mouse skin. Conclusion: PV antibodies altered O 2 respiration, disrupted electron transfer chain, and increased reactive oxygen species. Significance: Results provide the mechanism of therapeutic action and justify the use of mitochondria-protecting drugs in PV.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

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“…It is a rare disease-especially in the pediatric population, but it needs no less study because it does affect patients and also does affect certain groups of people more than others. Ashkenazi Jews and people from India and the Middle East have higher rates of the disease (Pisanti et al 1974). It is equally distributed among genders.…”

Section: Main Textmentioning

confidence: 99%

A brief review of pemphigus vulgaris

Sanders

2017

biomed dermatol

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Pemphigus vulgaris is an autoimmune disorder which presents with painful mucocutaneous blisters and erosions. On the skin, they are flaccid bullae or erosions, and on the mucosa, they present as erosions. This disease is rare but is devastating to those who have it; it also is related-perhaps genetically-to other autoimmune conditions. This is to say that a patient can develop pemphigus vulgaris if they have thyroiditis or diabetes mellitus. Biopsy is needed to obtain histopathological evidence of the breakdown of intercellular connections due to the autoimmune attack on components of desmosomes, which are responsible for intercellular integrity above the basement membrane. When these desmosomes are attacked, loss of connection ensues, and the cells break apart at these connections; this leads to fluid buildup, seen grossly as bullae. Treatment of the disease is difficult and sometimes unsafe. For decades, the mainstay of treatment has been glucocorticoids followed by other drugs. Unfortunately, these drugs are systemically absorbed, and the side effect profile can be unfavorable. In the past several years however, more innovative treatments have emerged that may help ease the cost and safety burden to patients. This review highlights the major points about pemphigus vulgaris, its pathophysiology, and its treatment.

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“…Coğrafik alanlara ve etnik gruplara göre farklılık göstermekle beraber yıllık insidans milyonda 0,76 ile 16,1 olgu arasında değişiklik göstermektedir 3,4 . Yakın ve Orta Doğu'da, Batı Avrupa ve Kuzey Amerika'ya göre daha sık görülmektedir 5,6,7 .…”

Section: Introductionunclassified

A retrospective study of 102 patients with pemphigus

Metin¹,

Kızılyel²,

Elmas³

et al. 2015

TURKDERM

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Background and Design:Pemphigus is a severe and life-threatening chronic autoimmune mucocutaneous blistering disease. The aim of this study was to evaluate and analyze the course, prognostic factors and epidemiological, clinical and therapeutic features of pemphigus in patients followed between 2004 and 2013. Materials and Methods: We performed a 10-year retrospective study of patients diagnosed with pemphigus in Erzurum. The parameters that were evaluated include age, sex, diagnostic methods, duration of hospitalizations, distribution of lesions, duration of treatment and therapeutic doses. Results:The results showed that the estimated annual incidence rate was 1.31 cases per 100.000 person-years. The male to female ratio was 1: 0.81. The mean age at onset of the disease was 48 years (range: 7-95 years). Thirty-six patients had only skin lesions and sixty-six cases had both skin and oral mucosal lesions. The majority of the patients (58.8%) with pemphigus were treated with middle or high-dose corticosteroids (40-160 mg/day). Conclusions: Pemphigus vulgaris is the most common clinical subtype in Erzurum and the mean age of the disease onset in the present study was found to be a decade earlier than in other parts of the world. The patients with both oral mucosa and skin involvement required higher corticosteroid doses and longer hospitalization time when compared to the patients with oral mucosa involvement alone. (Turkderm 2015; 49: 125-8)

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Pemphigus vulgaris: Incidence in Jews of different ethnic groups, according to age, sex, and initial lesion

Cited by 210 publications

References 4 publications

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

A brief review of pemphigus vulgaris

A retrospective study of 102 patients with pemphigus

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