Pemphigus Vulgaris in Childhood

Murphy, Patrick J.; Harrell, E. Richard

doi:10.1001/archpedi.1972.02110070120019

Cited by 13 publications

(14 citation statements)

References 8 publications

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“…It is important for clinicians to be aware of the existence of juvenile PV because early diagnosis may have prognostic implications (7,8). It is known from treating adults that earlier intervention is associated with greater rates of clinical remission (4).…”

Section: Resultsmentioning

confidence: 99%

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Pediatric Pemphigus Vulgaris: Durable Treatment Responses Achieved with Prednisone and Mycophenolate Mofetil (MMF)

Baratta¹,

Camarillo

Papa

et al. 2012

Pediatric Dermatology

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Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin and mucous membranes. Most cases occur in adults; cases in children are rare. This report describes the clinical presentations and treatment responses of three children with PV, as confirmed according to histology and indirect immunofluorescence studies. In all three cases, oral prednisone used in conjunction with mycophenolate mofetil (MMF) resulted in complete clinical remission, during which all pharmacotherapy was successfully discontinued. Resolution of the skin and mucosal blistering tended to occur quickly with prednisone, and after initiation of treatment with MMF, discontinuation of all pharmacotherapy was achieved within a range of 10 to 30 months in the three patients. One patient experienced a recurrence of genital lesions 19 months after discontinuation of therapy, but the condition remitted within 2 weeks with topical corticosteroid therapy. At the time of this report, the duration of complete remission ranged from 6 to 19 months. In summary, combination therapy with prednisone and MMF for pediatric PV appears to be a safe and effective approach that is associated with durable remission.

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Section: Resultsmentioning

confidence: 99%

“…Nearly all patients with PV develop painful oral erosions, and for some, this is the only clinical manifestation (1,8). Other mucous membranes reported to be involved include the larynx, esophagus, conjunctiva, nasal mucosa, vagina, penis, anus, and labia (1).…”

Section: Discussionmentioning

confidence: 99%

Pediatric Pemphigus Vulgaris: Durable Treatment Responses Achieved with Prednisone and Mycophenolate Mofetil (MMF)

Baratta¹,

Camarillo

Papa

et al. 2012

Pediatric Dermatology

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“…Sixteen cases of histologically proven pemphigus vulgaris in patients aged 16 and under have been reported since 1955 (Berger et al, 1973;Canizares & Dorsey, 1956;Elias et al, 1972;Hadida et al, 1966;Jordan, Ihrig & Perry, 1969;Khamaganova, Vedrova & Lukiyanova, 1977;Lehman, Landau & Newcomer, 1965;Menter, Bell & Wells, 1973;Mincer, Turner & Sibelius, 1975;Mintzer & Rubin, 1955;Murphy & Harrell, 1972;Paltzik & Laude, 1978;Petkov & Georgiva, 1966;Stiegleder, 1955;Walker, 1978;Wranicz, Sysa Jedrzejowska & Broniarezyk-Dyla, 1975). Ten were female and six male.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus vulgaris in adolescence

Sodaify

Vollum

1979

Clin Exp Dermatol

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“…Skin biopsies from all patients showed typical intraepidermal bullae with acantholysis. Indirect and direct immunofiuorescence studies reported in four of the cases Murphy & Harrell, 1972;Elias et al, 1972;Berger et al, 1973) were diagnostic and, as in adults, high doses of corticosteroids were required to control the disease. The use of immunosuppressive drugs in children with pemphigus has not yet been reported.…”

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confidence: 96%

The chronic acquired bullous diseases of childhood

Marsden¹,

Skeete²,

Black³

1979

Clin Exp Dermatol

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Due to their rarity, the chrotiic acquired bullous diseases of childhood have not yet beeti studied in detail. Constant changes in terminology and classification have so far achieved little apart from confusing clinicians. We have attempted, therefore, to interpret the literature, to define the diseases in question and have included some case reports of patients seen recently at St John's Hospital for Diseases of the Skin. The pemphigus groupWhen pemphigus occurs in children, the disease is chtiically, histologically and immunologically similar to that in adults. Beutner & Chorzelski (1976) reviewed 234 cases of pemphigus and found that the disease began before the age of 10 in four cases and between 11 and 20 years in nine. Eleven of these cases were female, an incidence 5-5 times higher than in other age groups, where the sexes are equally affected. This female preponderance in children with pemphigus has been noted elsewhere (Jordon et al, 1976). It is of interest that a much larger proportion of affected children had pemphigus foliaceus or erythematosus (sis out of thirteen cases) compared with adults (twenty-seven out of 221 cases).

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Pemphigus Vulgaris in Childhood

Cited by 13 publications

References 8 publications

Pediatric Pemphigus Vulgaris: Durable Treatment Responses Achieved with Prednisone and Mycophenolate Mofetil (MMF)

Pediatric Pemphigus Vulgaris: Durable Treatment Responses Achieved with Prednisone and Mycophenolate Mofetil (MMF)

Pemphigus vulgaris in adolescence

The chronic acquired bullous diseases of childhood

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