Pemphigus vulagis involving the esophagus

Oesophageal Pemphigus vulgaris

“…Since 1970 only 11 cases of oesophageal pemphigus have been reported including our case [3][4][5][6][7], Eight of them were middleaged women and in all except 1 the initial symptom of pemphigus was from the oral cavity. Three patients dramatically vomited large segments of oesophageal mucosa.…”

“…It may precede skin lesions by some months to years [1]. The blisters are caused by circulating autoantibodies against epi dermal intercellular cement substance, and therefore may also appear on mucosal sur faces with stratified squamous epithelium [2], Such involvement is infrequently seen on conjunctiva, pharynx, larynx, vagina, cervix uteri and anal mucosa [2], Pemphigus lesions of the oesophagus have only been reported in 10 cases [3][4][5][6][7][8]. We report another case in whom oesophageal erosions caused symptoms which might be misinterpreted as steroid ulcers and result in a decrease of the steroid dose instead of a reverse action.…”

Chronic Familial Benign Pemphigus

“…Nape of the neck, axillae, groin, perineum, genitofemoral folds, and inframammary areas are usually affected. Mucosae are generally spared, although involvement of the esophagus (70,71), oral mucosa (72), ocular conjunctiva (24) and vulva Besides the classical description, morphological variations may also be seen. They may either be hyperkeratotic, papulovesicular, neurodermatitic, vesiculopustular (22), papular (74), or erythrodermic (56).…”