Pemphigus vegetans arising in umbilicus: Successful clearance with intralesional steroid

Çetinarslan, Tubanur; Ermertcan, Aylin Türel; Temız, Peyker; Kurutepe, Semra

doi:10.4103/ijdvl.ijdvl_559_16

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…Recognition of this presentation for patients with PV is relevant; in fact, clinicians generally recall blistering diseases in the navel area only in pregnant and lactating females [ 8 ]. It is known that pemphigoid gestationis blisters occur in the umbilical region and later spread to the rest of the body [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Oral and Umbilical Locations as a First Sign of Pemphigus Vulgaris

Moussaoui

Oueslati

Oualha

et al. 2021

Case Reports in Dentistry

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The place of pemphigus vulgaris (PV) among autoimmune bullous diseases (AIBD) is well established. It is an acquired chronic, autoimmune, vesiculobullous disease in which IgG antibodies target desmosomal proteins to produce intraepithelial mucocutaneous blistering. The diagnosis is often challenging for the clinicians. It requires a combination of three major features: clinical, histopathological, and immunological. Clinically, oral lesions are the first manifestations of the disease in 50-90% of the patients with widespread blisters affecting the oral mucosa. On the skin, lesions are characterized by flaccid blisters that rapidly progress into erosions and crust formation. Umbilical lesions as a clinical manifestation of PV are peculiar and have rarely been reported, and they are not yet completely elucidated. Umbilical region involvement in patients with pemphigus was assessed in a limited study totalling just 10 patients. This localisation may be a valuable hint easing the diagnosis at the clinical level for patients with oral mucosal blisters. Dentists must be familiar with the clinical manifestations of PV to make an early diagnosis and start an early treatment which determines the prognosis of the disease. To the best of the authors’ knowledge, the coexistence of these lesions with the oral lesions as a first sign of PV in the absence of skin involvement was reported in only one case of pemphigus vegetans (PVe). In this paper, we describe an observation of a female patient that was diagnosed with PV that begun with simultaneous oral and umbilical locations which coexisted for a period of 4 months before the appearance of other cutaneous lesions. We highlight the role of dentists, by being familiar with the clinical manifestations of PV, to make an early diagnosis to start an early treatment which determines the prognosis of the disease and to follow closely the evolution of lesions to change treatment if required. We also discuss the clinical, histological, and immunological features of the disease that enabled the differential diagnosis as well as the appropriate therapeutic management.

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Section: Discussionmentioning

confidence: 99%

Simultaneous Oral and Umbilical Locations as a First Sign of Pemphigus Vulgaris

Moussaoui

Oueslati

Oualha

et al. 2021

Case Reports in Dentistry

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“…Hallopeau tipinde ise püstüler lezyonlar gözlenir ve Neuman tipine göre daha iyi seyirlidir. Oral lezyonlar her zaman bulunur, "pyodermatitis-pyostomatitis vegetans" olarak isimlendirilir (1,2,19,(28)(29)(30).…”

Section: Pemfi̇gus Vejetans (Pvej)unclassified

“…Nötrofilik spongiyozis, subkorneal yerleşimli püstül oluşumları, intraepidermal vezikülasyon gözlenir. Epidermiste belirgin akantoliz yoktur ya da minimal bir akantoliz gözlenir (6,28,35).…”

Section: Histopatolojik Bulgularunclassified

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Direct immunofluorescence microscopy findings of autoimmune vesiculobullous dermatitis

Lebe¹

2019

JCurrPath

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Otoimmün vezikülobüllöz dermatitler deri ve müköz membranlardaki adezyon moleküllerine karşı gelişen antikorlar ile karakterize heterojen bir hastalık grubudur. Erken dönemde kesin tanı ve ayırıcı tanı yapılması hastaların tedavilerinin düzenlenmesi ve prognozları açısından çok önemlidir. Kesin tanı klinik bulgular, histopatolojik inceleme, immünofloresan mikroskopi ve seroloji ile konulur. Perilezyonel deri alanından yapılan biyopsi örneğinin direkt immünofloresan mikroskobik incelenmesi %98 özgüllük ve %82-91 duyarlılık ile serolojik incelemelerin çeşitli avantajlarına rağmen tanısal bir altın standarttır. Dermoepidermal bileşke ya da interfazın intakt olduğu, bül kenarı perilezyonel alandan alınan örneğin direkt immünofloresan ile incelenmesi temeldir. Otoimmün büllöz hastalıkların kesin tanısında sadece ışık mikroskobik inceleme yeterli olmayp, mutlaka direkt immünofloresan mikroskopi eklenmelidir. Bu derlemede otoimmün vezikülobüllöz hastalıkların direkt immünofloresan bulguları klinik ve histopatolojik bulguları ile birlikte sunulacaktır.

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Pemphigus vegetans localised to the soles of both feet: Successful clearance with intralesional corticosteroid

Liu

Zong

et al. 2020

Aust J Dermatology

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Pemphigus vegetans arising in umbilicus: Successful clearance with intralesional steroid

Cited by 6 publications

References 4 publications

Simultaneous Oral and Umbilical Locations as a First Sign of Pemphigus Vulgaris

Simultaneous Oral and Umbilical Locations as a First Sign of Pemphigus Vulgaris

Direct immunofluorescence microscopy findings of autoimmune vesiculobullous dermatitis

Pemphigus vegetans localised to the soles of both feet: Successful clearance with intralesional corticosteroid

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