Pemphigus vegetans: a clinical, histological, immunopathological and prognostic study

Zarâa, I.; Sellami, Ahmed; Bouguerra, Chaker; Sellami, M.; Chelly, Inès; Zitouna, M; Makni, S.; Hmida, A. Ben; Mokni, M.; Osman, A. Ben

doi:10.1111/j.1468-3083.2010.03939.x

Cited by 71 publications

(105 citation statements)

References 45 publications

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“…In addition, both cases showed strong IgG reactivity with Dsc3. Considering that clinical features of both Neuman-and Hallopeau-types concur in some cases of pemphigus vegetans, 2 the results of the present study may suggest a common pathomechanism in the Hallopeau-type of pemphigus vegetans.…”

Section: Discussionmentioning

confidence: 73%

Two Cases of Pemphigus Vegetans With IgG Anti–Desmocollin 3 Antibodies

et al. 2013

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Section: Discussionmentioning

confidence: 73%

Two Cases of Pemphigus Vegetans With IgG Anti–Desmocollin 3 Antibodies

et al. 2013

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“…Its incidence is reported to be higher in North Africa and more specifically Tunisia (1). Nevertheless, to our knowledge, this is the first reported case of pemphigus vegetans in the Nordic countries (1).…”

Section: Diagnosis: Pemphigus Vegetans Hallopeau Typementioning

confidence: 47%

Vegetating Inguinal and Perianal Lesions: A Quiz

Salah¹

2015

Acta Derm Venerol

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A 72-year-old woman was referred to the dermatology department with a one-month history of non-itching skin lesions in the groin. The rash had been initially diagnosed as impetigo as the lesions started as pustules. However, no improvement was noted on antibiotic treatment. The lesions changed to become larger, warty and vegetating (Fig. 1). Smaller lesions were seen perianally. No vesicles or bullae were noted. She denied loss of appetite or weight loss. There was no relevant drug history.Laboratory tests showed erythrocyte sedimentation rate of 80 mm/h (normal < 28 mm/h) and positive haemoglobin in one out of 3 foecal samples. A gastrointestinal investigation including endoscopy was negative.A skin biopsy was taken (Fig. 2). At the following visit, the patient developed papules and early exophytic plaques on the dorsal side of the tongue. Fig. 1. Vegetating red plaques in the left and right inter triginous regions.Fig. 2. Histological picture (H&E staining): (A) Prominent acanthosis with intraepidermal abscesses. (B) At higher magnification, suprabasal clefts, rounded acantholytic cells and eosino philic infiltrate are seen.

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“…Although the mortality associated with pemphigus has declined, long-term systemic corticosteroid use is associated with major side effects such as hypertension, diabetes mellitus and osteoporosis. However, isolated steroid treatment is often insufficient in achieving disease remission 4. In addition, patients on chronic immunosuppressive therapy are often susceptible to opportunistic infections, which may lead to sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…Research has shown that agents such as azathioprine, mycophenolate mofetil and dapsone may improve the rate of remission in these patients 1 4. Recently, rituximab therapy was shown to be useful in treating recalcitrant PVeg.…”

Section: Discussionmentioning

confidence: 99%

Pemphigus vegetans with coexistent herpes simplex infection and deep venous thrombosis of the lower extremities

et al. 2015

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An elderly patient presented with a 4-month history of eroded hypertrophic condylomatous plaques with areas of vesiculation on the groin and lower extremities bilaterally, associated with swelling. Biopsy and immunofluorescence studies confirmed the diagnosis of pemphigus vegetans (PVeg). Further clinical evaluation revealed deep venous thrombosis of the lower extremities and septic shock from secondarily infected pemphigus lesions. Fluid obtained from vesicles was positive for herpes simplex virus (HSV) via PCR-based testing. The patient was therapeutically anticoagulated, treated with high-dose corticosteroid therapy, broad-spectrum intravenous antibiotics and acyclovir. This case represents a constellation of diagnoses not previously described. Although pemphigus vulgaris has been linked to thromboembolic events and has been associated with HSV, these associations have not been previously reported in PVeg. The coexistence of these diseases should encourage vigilance in the clinical work up of a patient with PVeg.

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Pemphigus vegetans: a clinical, histological, immunopathological and prognostic study

Abstract: The P Veg seems to be more frequent in Tunisia with high rate of mortality.

Cited by 71 publications

References 45 publications

Two Cases of Pemphigus Vegetans With IgG Anti–Desmocollin 3 Antibodies

Two Cases of Pemphigus Vegetans With IgG Anti–Desmocollin 3 Antibodies

Vegetating Inguinal and Perianal Lesions: A Quiz

Pemphigus vegetans with coexistent herpes simplex infection and deep venous thrombosis of the lower extremities

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