Abstract:A study of pemphigus in New Delhi, India, and Oxford, UK, was undertaken including 20 patients in Oxford and 50 in New Delhi. Data included clinical and histological subtypes and socio-economic data; patients were HLA typed. In New Delhi pemphigus vulgaris predominated, but in Oxford pemphigus vulgaris and pemphigus foliaceus have equal prevalence. Disease distribution with sex was the same, but age at onset was significantly lower in New Delhi (p = 0.0019). HLA typing in pemphigus vulgaris patients revealed a… Show more
“…Our results confirm previous reports showing a strong association of PV with DQB1*0503 which is in linkage disequilibrium with DR14 alleles [3,4,5,8,10,12,13,14,15,16,17]. Since the DQB1*0503 PV patients had various DRB1*14 related alleles, one alternative The AA residues are shown using the letter code.…”
Section: Pemphigus Vulgarissupporting
confidence: 90%
“…The DRB1*1401 or 1404 alleles were found associated with PV in non-Jewish patients of European ancestry (Italy, Sardinia, Spain, Boston area) [3,4,5,6] and in Asian populations (India, Pakistan, Japan) [12,13,14,15,16,17].…”
“…Our results confirm previous reports showing a strong association of PV with DQB1*0503 which is in linkage disequilibrium with DR14 alleles [3,4,5,8,10,12,13,14,15,16,17]. Since the DQB1*0503 PV patients had various DRB1*14 related alleles, one alternative The AA residues are shown using the letter code.…”
Section: Pemphigus Vulgarissupporting
confidence: 90%
“…The DRB1*1401 or 1404 alleles were found associated with PV in non-Jewish patients of European ancestry (Italy, Sardinia, Spain, Boston area) [3,4,5,6] and in Asian populations (India, Pakistan, Japan) [12,13,14,15,16,17].…”
“…7,8 A previous study from New Delhi, India, showed a mean age at onset of 41.2 years. 11 We observed a mean age at onset of 39.27 years for males and 38.57 years for females. Although the exact explanation for the earlier age at onset is not clear, environmental factors may, in some ways, be operative 19,20 because a younger age at onset is observed in Asian, Middle Eastern, and North African regions.…”
Section: Pemphigus In North Indiamentioning
confidence: 63%
“…The usual age at onset of the disease was observed to be between the fifth and sixth decades of life in North American, European, South African, and Mali patients, [9][10][11]13,18 whereas a younger age at onset, predominantly in the third to fourth decades, has been observed from Tunisia and Kuwait. 7,8 A previous study from New Delhi, India, showed a mean age at onset of 41.2 years.…”
North Indian patients of pemphigus have a relatively younger age at onset. The majority of patients were from the states of Punjab and Haryana. The response to DCP therapy was good, and with DCP, the additional dose of oral steroids that was required to control the activity of the disease was less than 30 mg/d, which is much less than the dosage used in the standard conventional regimens.
“…Einige Untersucher fanden ein geringfügig höheres Auftreten des PV bei Männern [14,25]. Aber auch das gleich häufige Auftreten von Pemphiguserkrankungen bei Frauen und Männern wurde berichtet [4,7,10,13,24,28].…”
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