Pemphigus From the Laryngologist's Standpoint

New, Gordon B.; O’leary, Paul A.

doi:10.1001/archotol.1925.00560010645004

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Before corticosteroids, the mortality rate ranged from 70% to 100%.4,5 Early treatments included coagulin, iron cacodylate, immune sera from the "bacteria of pemphigus," and intravenous administration of gentian violet and membromin. 2 Since the advent of corticosteroids in the early 1950s,10 the mortality rate associated with pemphigus vulgaris has dropped to 7.6%. 5 Steroids are thought to cause the production of inhibitors of plasminogen activator.4 Certain modes of steroid therapy, such as lowdose steroids alone, high-dose steroids only (for severe cases), or initial high-dose steroids followed by low-dose maintenance steroids, treat pemphigus vulgaris adequately and may avoid many steroid-related complications such as infection, cushingoid symptoms, occult gastrointestinal bleeding, diabetes , peripheral edema, and psychological manifestations.…”

Section: Discussionmentioning

confidence: 99%

Primary laryngeal and nasal septal lesions in pemphigus vulgaris

Saunders

Gentile²,

Lobritz³

1992

Journal of Osteopathic Medicine

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Synchronous laryngeal and nasal septal lesions in pemphigus vulgaris are rare. The authors report a case of pemphigus vulgaris in an elderly man who was seen with lesions of the supraglottic larynx and nasal septum. The classic skin changes of pemphigus eventually developed, and the patient responded to daily treatments of 80 mg of prednisone. Steroids and immunosuppressive agents remain the treatment of choice, but a favorable prognosis is still dependent on early diagnosis and institution of therapy.

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Section: Discussionmentioning

confidence: 99%

Primary laryngeal and nasal septal lesions in pemphigus vulgaris

Saunders

Gentile²,

Lobritz³

1992

Journal of Osteopathic Medicine

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“…It is now generally agreed to reserve the term for four varieties of bulbous eruptions: (1) Among these forms there is a considerable difference in prognosis and course.…”

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confidence: 99%