Pemphigus foliaceus transforming into pemphigus herpetiformis

Annular Erythematous Plaques With Overlying Blisters in a Cluster of Jewels Pattern

“…PH is speculated to exist within a spectrum alongside PV and pemphigus foliaceus, with reported transitions between these diseases, likely associated with epitope expansion mechanisms . In contrast to classic pemphigus, PH shares similarities with other pemphigus subtypes that showcase substantial inflammation sometimes leading to acantholysis .…”

“…PH is speculated to exist within a spectrum alongside PV and pemphigus foliaceus, with reported transitions between these diseases, likely associated with epitope expansion mechanisms. 7 In contrast to classic pemphigus, PH shares similarities with other pemphigus subtypes that showcase substantial inflammation sometimes leading to acantholysis. 8 Notably, many patients with PH and desmoglein-3 autoantibodies (typically associated with mucosal involvement in PV) do not exhibit mucosal lesions, suggesting the involvement of alternative pathophysiologic mechanisms in shaping the distinct phenotype of PH and setting it apart from the classic form of pemphigus.…”