Pemphigus foliaceus in young women. An endemic focus in the Sousse area of Tunisia

Morini, J.-P.; Jomaa, B; Gorgi, Yosrl; Saguem, Mohamed H.; Nouira, R.; Roujeau, Jean‐Claude; Revuz, J

doi:10.1001/archderm.129.1.69

Cited by 69 publications

(75 citation statements)

References 18 publications

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“…The roles of IgG autoantibodies and complement in lesional EPF skin has been previously documented [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 93%

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Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Velez¹,

Roselino²,

Howard³

2013

Our Dermatol Online

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Introduction: Pemphigus foliaceus (PF) is endemic in some South American countries, especially in Colombia and Brazil; in Brazil, it is also known as fogo selvagem (FS). We aimed to study the presence of mast cells and the expression of the mast/stem cell growth factor receptor (c-kit/CD117) in PF skin biopsies, as well as the role of IgE in the disease pathogenesis. Methods: Forty-four skin biopsies from patients affected by endemic PF (EPF) (30 patients from El Bagre, Colombia, and 14 from the northeastern region of São Paulo State, Brazil), 48 control biopsies from Colombian and Brazilian endemic areas, and additional control biopsies from none endemic areas in Colombia and the USA non were studied. Immunohistochemistry (IHC) was performed to evaluate skin biopsies with anti-mast cell tryptase (MCT), anti-c-kit and anti-IgE antibodies. We also searched for serum IgE in 30 EPF and 30 non-atopic controls from the El Bagre region via ELISA. In our El Bagre patients and controls, we also searched for IgE in skin samples by direct immunofluorescence. Results: In 100% of the EPF biopsies, MCT, c-kit and IgE were identified with stronger expression relative to control biopsies, especially in the inflammatory infiltrates around upper dermal blood vessels and dermal eccrine glands. IgE staining was positive along the BMZ in some EPF skin samples. The DIF results confirmed a linear deposition of IgE at the BMZ. Increased IgE serum levels were also noted in PF patients relative to controls.. Conclusions:In patients with EPF, the observed increased expression of MCT, c-kit and IgE in lesional skin, associated with higher serum IgE levels may indicate possible IgE participation in the antigenic response.

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“…The roles of IgG autoantibodies and complement in lesional EPF skin has been previously documented [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 93%

“…Endemic pemphigus foliaceus (EPF) is an autoimmune blistering skin disease presenting in well-defined geographic regions [1][2][3][4][5][6][7]. The roles of IgG autoantibodies and complement in lesional EPF skin has been previously documented [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Velez¹,

Roselino²,

Howard³

2013

Our Dermatol Online

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“…Table 1 shows that there was no significant association between allelic frequencies of C coding region markers and PF or PV. Since pemphigus, like other autoimmune diseases such as systemic lupus erythematosus, may be genetically heterogeneous, we also determined the genotypic frequencies of Km allotypes in the characteristic target population of Tunisian pemphigus 4 ie young females р35 years (Table 2). Again, no Km allogenotype was significantly increased in this population.…”

Section: Distribution Of Km Allogenotypesmentioning

confidence: 99%

“…3 Recently, pemphigus has also been shown to be more frequent in Tunisia (seven cases per million per year) as a consequence of a higher incidence rate of PF which particularly involves young females. 2,4,5 Susceptibility to pemphigus is partly determined by genetic factors among which HLA class II genes have been identified. Indeed, DR4 and DR14 haplotypes and, more precisely, DRB1*0402, DRB1*1401 and DRB1*1404 are strongly associated with PV in different ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Pemphigus is not associated with allotypic markers of immunoglobulin kappa

et al. 2002

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“…Pemphigus is no exception to this. In fact, cases of pemphigus triggered by emotional stress are not exceedingly rare [74, 75, 76, 77, 78]. Furthermore, in most patients with idiopathic pemphigus the possible existence of a psychological precipitating factor is overlooked or ignored by both the patient and the physician.…”

Section: Emotional Stressmentioning

confidence: 99%

Precautions and Suggestions for Pemphigus Patients

2001

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The onset and course of pemphigus are often the result of an interaction between predisposing genetic factors and environmental triggering agents. The latter are heterogeneous, numerous and increasing, ranging from drug intake (the commonest cause of pemphigus induction) to the exposure to physical agents (heat, UV and ionizing rays, surgical and cosmetic procedures), viral infections (especially by herpesvirus), contact dermatitis, certain diet ingredients and even emotional stress. Alerting physicians and pemphigus patients to the effects that unsuspected precipitating factors may have on the progression of the disease is an important task. In fact, avoiding or limiting deleterious habits (e.g. overindulging in unnecessary drugs) and suggesting alternative ways (e.g. substituting potentially pemphigus-inducing drugs with others considered harmless in this respect) may be a useful precaution in the management of pemphigus patients, since it can improve the efficacy of conventional treatments, reduce the risks of relapses and sometimes result in a cure.

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Pemphigus foliaceus in young women. An endemic focus in the Sousse area of Tunisia

Cited by 69 publications

References 18 publications

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Mast cells, Mast/Stem Cell Growth Factor receptor (c-kit/cd117) and IgE may be integral to the pathogenesis of endemic pemphigus foliaceus

Pemphigus is not associated with allotypic markers of immunoglobulin kappa

Precautions and Suggestions for Pemphigus Patients

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