Pemphigus: Etiology, pathogenesis, and inducing or triggering factors: Facts and controversies

Oral Pemphigus Vulgaris: The Importance of Patient’s Adherence

“…Without any treatment, PV lesions can spread more extensive and life-threatening fatal within 1 to 3 years, because of loss of fluid and protein or opportunistic infection. 2 The wide variety of therapies can be used but no one can guarantee a permanent remission and sometimes recurrence may still happen. 6 The patient was also treated with steroid sparing agents such as azathioprine and mycophenolate mofetil.…”

“…Auto antibodies circulating induce loss of adhesion cell in epithelial suprabasal and forming of intraepithelial vesicles or bulla. 2 The patient was treated with systemic corticosteroid for his skin lesion, while the oral lesion was treated with topical corticosteroid. Systemic and topical corticosteroids are the first line therapy of PV.…”

“…The etiology of PV is unknown but strongly associated with genetic some HLA class II genus. 2 Some inducing factors such as drug intake, viral infections, ultra violet radiation, nutrition, chemicals, and emotional stress. 2 The patient in our report was never in complete remission, since the lesion of PV can be declared to have complete remission without treatment when no new lesions appear without therapy for two months.…”

“…2 Some inducing factors such as drug intake, viral infections, ultra violet radiation, nutrition, chemicals, and emotional stress. 2 The patient in our report was never in complete remission, since the lesion of PV can be declared to have complete remission without treatment when no new lesions appear without therapy for two months. 1 The relapses of this case might happen due to the frequent discontinuation of medication or the presence of inducing factors that had not been identified yet.…”

“…1 PV can occur in all racial and ethnic groups with the highest incidence in Ashkenazi Jews during 40-60 years old. 2 Histological examination of PV will show acantholisys.…”