Pemphigoïde anti-p200 : réponse spectaculaire à la dapsone

Munsch, C.; Prey, S.; Joly, P.; Meyer, Nicolas; Lamant, Laurence; Livideanu, C. Bulai; Viraben, R.; Paul, C.

doi:10.1016/j.annder.2011.05.024

Cited by 7 publications

(3 citation statements)

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“…On salt-split skin, binding to the dermal side of the split was reported in 90 patients (83.3%) and binding to both the dermal and epidermal sides in 16 patients (14.8%) (Table 3). Immunoblot analysis demonstrated reactivity to the 200 kDa protein in all 111 patients tested using human dermal extract ( n = 108), epidermal extracts ( n = 11) (10, 37) and keratinocytes extracts ( n = 2) (32). Sera of several patients were tested on multiple extracts, and 10 of the 11 patients reacting to the epidermal extract were also seropositive on dermal extracts (10).…”

Section: Resultsmentioning

confidence: 99%

Anti-p200 Pemphigoid: A Systematic Review

Kridin

Ahmed

2019

Front. Immunol.

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The many clinical aspects of anti-p200 pemphigoid are not well-characterized. We aimed to analyze and correlate known existing data on the epidemiological, clinical, histological, and immunological features of anti-p200 pemphigoid. We performed a review using Medline, Embase, and Web of Science databases (1900–2018). Case reports and series of patients were included. A total of 68 eligible studies that comprised 113 anti-p200 pemphigoid patients were included in the qualitative analysis, where there was a mean age of onset of 65.5 years. All patients presented with bullae/vesicles, and 54.3% had urticarial plaques. A similarity to bullous pemphigoid was reported in 66.1% of cases, but palmoplantar (51.4%), cephalic (40.3%), and mucosal (38.5%) involvement, besides frequent development of scars/milia (15.7%), were reported. Autoantibodies against recombinant laminin γ1 were detected in the sera of 73.1% of patients. Psoriasis was present in 28.3% of anti-p200 pemphigoid patients, particularly among Japanese patients (56.4%). The incidence of pustular psoriasis in this subgroup, was significantly greater than in the normal population. In conclusion, the diagnosis of anti-p200 pemphigoid may be suspected when a subepidermal autoimmune blistering disease develops in a younger age group, along with significant acral and cephalic distribution and mucosal involvement.

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Section: Resultsmentioning

confidence: 99%

Anti-p200 Pemphigoid: A Systematic Review

Kridin

Ahmed

2019

Front. Immunol.

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“…Two of these four patients relapsed during the follow-up. Nine patients were treated with superpotent topical corticosteroids (clobetasol propionate cream 20-40 g per day) (patients [6][7][8][9][10][11][12][13][14]. Six patients (66%) achieved disease control after a mean delay of 10 days.…”

Section: Treatment and Clinical Coursementioning

confidence: 99%

“…3 Most of these are case reports. [4][5][6][7][8][9] Limited data on the clinical course of these patients are available. The objective of this study was to describe the clinical and immunological features and the course of anti-p200 pemphigoid in a series of 14 patients by immunoblotting detection of serum antibodies on a 200-kDa band of laminin c1 on dermal extracts.…”

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confidence: 99%