Pemetrexed loaded gold nanoparticles as cytotoxic and apoptosis inducers in lung cancer cells through ROS generation and mitochondrial dysfunction pathway
Baby Shakila P,
Tamilmani Periasamy,
Abdullah A. Alarfaj
et al.
Abstract:Supramolecular nanoparticles containing peptides and drugs have recently gained recognition as an effective tumor treatment drug delivery system. A multitarget drug termed pemetrexed is effective against various cancers, including nonsmall cell lung cancer. The work aims to establish the capability of pemetrexed gold nanoparticles (PEM‐AuNPs) to induce apoptosis and explore molecular changes. X‐ray diffraction, Fourier‐transform infrared spectroscopy, ultraviolet–visible spectroscopy, scanning electron microsc… Show more
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