Pemetrexed-induced edema of the eyelid

Guhl, Guillermo; Díaz-Ley, B.; Sánchez‐Pérez, Javier; Jimenez, Ulpino; García‐Diez, Amaro

doi:10.1016/j.lungcan.2010.04.024

Cited by 13 publications

(3 citation statements)

References 8 publications

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“…[3] Periorbital edema was associated to an ankle edema in one patient and macular erythematous eruption of the trunk in another. [12] In our case, the edema of eyelid was associated to edema of the soles of feet.…”

Section: Discussionmentioning

confidence: 58%

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Eyelid and feet edema induced by pemetrexed

Kastalli¹,

Charfi

Sahnoun³

et al. 2016

Indian J Pharmacol

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Pemetrexed is an anti-metabolite that targets multiple enzymes in folate pathway. The main toxicities associated with pemetrexed are asthenia, nausea, diarrhea, myelosuppression, and rash. Few cases of pemetrexed induced cutaneous adverse event have been reported, mainly periorbital-facial edema and edema of the limbs. We report a case of pemetrexed-induced edema of the eyelid and feet in a patient with adenocarcinoma of the lung.

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Section: Discussionmentioning

confidence: 58%

“…Few cases of pemetrexed-induced cutaneous adverse events have been reported, mainly periorbital-facial edema. [12]…”

mentioning

confidence: 99%

Eyelid and feet edema induced by pemetrexed

Kastalli¹,

Charfi

Sahnoun³

et al. 2016

Indian J Pharmacol

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“…Main secondary effects associated with pemetrexed are myelosuppression, renal toxicity and macular skin rash. 1,9 Regarding pemetrexed-associated cutaneous lesions, little has been published about the clinicopathological findings or the mechanism of their development. 3 More recent reports just highlight pemetrexedinduced sclerodermia based on the clinical evolution of the lesions.…”

mentioning

confidence: 99%

Pemetrexed‐induced painful erythematous nodules in both legs in a patient with recurrent mesothelioma

et al. 2017

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Pemetrexed (Alimta, Eli Lilly, Brussels, Belgium) is an approved antifolate drug, used as a first-line treatment for malignant pleural mesothelioma (combined with cisplatin) and for non-small cell lung cancer (NSCLS). It has been approved by both the European MEdicines Agency (EMEA) and the US Food and Drug Administration (FDA).This drug inhibits pyrimidine and purine synthesis, thus causing cell-cycle arrest 1 by modifying the action of dihydrofolate reduc-

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Antimetabolite Reactions

Chu¹,

Kong²

2013

Dermatologic Principles and Practice in Oncology

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Pemetrexed-induced edema of the eyelid

Cited by 13 publications

References 8 publications

Eyelid and feet edema induced by pemetrexed

Eyelid and feet edema induced by pemetrexed

Pemetrexed‐induced painful erythematous nodules in both legs in a patient with recurrent mesothelioma

Antimetabolite Reactions

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