Pemetrexed-based first-line chemotherapy had particularly prominent objective response rate for advanced NSCLC: A network meta-analysis

Abstract

Objective The aim of the present work was to investigate the clinical efficacy of first-line chemotherapy regimens in the treatment of advanced non-small cell lung cancer (NSCLC) through a comprehensive network meta-analysis (NMA). Methods The prospective randomized controlled clinical trials relevant to 10 first-line chemotherapy regimens in the treatment of advanced NSCLC were systematic electronic search in the databases of Pubmed, Embase, Cochrane Library and CNKI. The combined direct or indirect objective response rate (ORR) between each of the 10 first-line chemotherapy regimens was calculated. Results Seventeen prospective clinical trials of first-line chemotherapy regimens in treatment of advanced NSCLC were included in the NMA. The 10 treatment regimens including A = cisplatin + gemcitabine, B = carboplatin + gemcitabine, C = gemcitabine, D = carboplatin + paclitaxel, E = paclitaxel + gemcitabine, F = docetaxel + carboplatin, G = gemcitabine + vinorelbine, H = pemetrexed + carboplatin, I = cisplatin + pemetrexed and J = cisplatin + docetaxel were compared in the present NMA. Direct pooled results indicated that the ORR was not statistically different (P all > 0.05). However, NMA showed that the combined ORR for regimens A (OR = 1.47, 95% CI: 0.80–2.81), B (OR = 3.22, 95% CI: 1.45–6.923), D (OR = 3.30, 95% CI: 1.22–9.33), E (OR = 4.36, 95% CI: 1.64–12.82), G (OR = 3.72, 95% CI: 1.12–12.83) and I (OR = 5.80, 95% CI: 2.04–17.86) was superior to regimen C. Rank probability analysis indicated that regimen C = gemcitabine and regimen I = cisplatin + pemetrexed had the highest probability of inferior and superior treatment ORR among the 10 first-line chemotherapy regimens. Conclusion Cisplatin + pemetrexed may have particularly prominent ORR for advanced NSCLC as the first-line chemotherapy regimen.

[Retracted] Study on the Evaluation of Lung Cancer Patients from the Three Aspects of Emotion

“…In Figure 1, the current state not only depends on the previous state in the sequence M where it is located but also depends on the previous state in the other sequence N. is model has been widely used in computer vision and digital communications. [16]. In addition, P(M t+1 |M t ,N t ) is the state transition probability of the first sequence, and P(N t+1 |M t ,N t ) is the state transition probability of the second sequence.…”

“…In a CHMM containing two state sequences, O ={ A 1 T , B 1 T } represents an observation sequence, where A 1 T ={ a 1 ,…, a T } represents the first observation sequence; similarly, B 1 T ={ b 1 ,…, b T } represents the second observation sequence. S ={ X 1 T , Y 1 T } is a sequence of states, where X 1 T ={ x 1 ,…, x T } represents the state of the first sequence; similarly, Y 1 T ={ y 1 ,…, y T } represents the second sequence [ 16 ]. In addition, P ( M t +1 | M t , N t ) is the state transition probability of the first sequence, and P ( N t +1 | M t , N t ) is the state transition probability of the second sequence.…”

Continuous intravenous infusion of recombinant human endostatin using infusion pump plus chemotherapy in non-small cell lung cancer

“…The median survival of stage IV patients is less than nine months. Chemotherapy regimens for NSCLC mainly include platinum-containing double-drug chemotherapy or gemcitabine and docetaxel monotherapy[ 3 ]. However, the efficacy and safety of the current regimens is unsatisfactory.…”