Pemetrexed as a Component of First-, Second- and Third-line Chemotherapy in Treating Patients with Metastatic Lung Adenocarcinoma

Clinical Application of Recombinant Human Endostatin in Postoperative Early Complementary Therapy on Patients with Non-small Cell Lung Cancer in Chinese Mainland

“…However, the long-term survival rate of lung cancer patients has not been significantly improved (Lu et al, 2013;Yan et al, 2013;Hou et al, 2014;Ji et al, 2014). The 5-year survival rate of NSCLC patients undergoing surgeries is only 30%~40% in the maximum, with the cause of death being tumor recurrence and metastasis, thus leading to the unsatisfactory clinical outcomes (Fei et al, 2013;Cui et al, 2014;Huang et al, 2014). How to reduce the postoperative recurrence and metastasis so as to prolong the survival time and improve …”

CD3+CD4+and CD3+CD8+Lymphocyte Subgroups and their Surface Receptors NKG2D and NKG2A in Patients with Non-small Cell Lung Cancer

“…Therefore, patients with lung cancer are always in advanced ones when diagnosed with highly limited recovery rate by systematic treatment, for which early diagnosis and treatment become one of the topics in studying lung cancer (Huang et al, 2013;. In recent years, with the rapid development of molecular biology and immunology and the multidisciplinary cross integration, achievements have been made in the research of mutual regulation among immunological cells in tumor tissues (Sánchez et al, 2014;.…”

YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells

“…The elevated expression level and the cell surface level of TNFRSF10B induced by some chemotherapeutic agents play a critical role during the apoptosis of tumor cells perhaps in a ligand-independent manner. Our previous study indicated that pemetrexed (PEM), an inhibitor of folic acid synthesis used for the treatment of NSCLC patients currently 10,11 , can induce apoptosis by upregulating the expression of TNFRSF10B in NSCLC cells 12 . Therefore, as an important mediator of the extrinsic apoptotic signaling pathway, TNFRSF10B has been attracted much more attention on cancer therapy [13][14][15] .…”