Pembrolizumab dramatically resolves choroidal metastatis from esophageal adenocarcinoma and restores vision: a case report

Abstract

Esophageal adenocarcinoma historically is an aggressive cancer with poor long-term survival. Ocular metastasis secondary to gastrointestinal malignancy is rare. In managing patients with ocular metastasis, quality of life (specifically vision preservation) is one of the most important factors patients and providers consider when deciding on a treatment regimen. Anti-programmed cell death-1 (PD-1) and PD-1 ligand (PD-L1) inhibitors such as pembrolizumab have shown promising results as second-line therapy for patient with metastatic malignancy. We describe a novel case of a functionally monocular patient with known metastatic esophageal adenocarcinoma who developed poor vision and a large choroidal lesion in his better seeing eye. The lesion regressed and vision restored to 20/20 after treatments with pembrolizumab in this case report.

Choroidal Metastasis From Papillary Renal Cell Carcinomas: A Case Report and a Review of the Literature

“…Immunotherapy has recently become the mainstream medical therapy for several cancers, including RCC. Its efficacy for choroidal metastasis has been reported [ 5 , 6 ]. On the other hand, SRT, plaque radiotherapy, transpupillary radiotherapy, or photodynamic therapy are selected for solitary metastasis.…”