PEMBERIAN AIR REBUSAN DAUN SIRIH MERAH (Piper crocatum Ruiz &amp;Pav) TERHADAP KADAR GLUKOSA DAN KOLESTEROL DARAH MENCIT PUTIH JANTAN

Shinta, Dewi; Sudyanto, Sudyanto

doi:10.31958/js.v8i2.480

Cited by 4 publications

(5 citation statements)

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“…The test animals used are male house mice aged 2-3 months with a body weight of 20-25 g. The preparation of test animals was conducted according to Shinta and Sudyanto (2016) with some modifications. There are 15 test animals, distributed across five testing groups.…”

Section: Preparation Of Test Animalsmentioning

confidence: 99%

The Potential of Donkey’s Ear Abalone (Haliotis asinina Linnaeus, 1758) as an Antibacterial Agent and Its Effect on Blood Cholesterol Reduction in Mice (Mus musculus Linnaeus, 1758)

2024

JFE

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Infectious diseases primarily caused by pathogenic bacteria like Staphylococcus aureus and Escherichia coli are commonly treated with antibiotics, which interfere with the growth or kill the bacteria by disrupting metabolism (Mancuso et al., 2021). Incorrect antibiotic use can lead to negative health effects and contribute to multi-drug resistance (Fernández et al., 2016). Marine organisms such as abalones have the potential as an alternative agent of new antibacterial. Abalon extracted with ethyl acetate has been reported to have antimicrobial activity and anthelmintic activity and contains secondary metabolite compounds such as alkaloids, terpenes, and flavonoids (Tortorella et al., 2021).Cholesterol is a vital element necessary for regulating chemical processes in the human body (Luo et al., 2020). However, excessive cholesterol can cause hypercholesterolemia and fat accumulation on the walls of blood vessels, thereby triggering symptoms of atherosclerosis and a decrease in proteins in the body's tissue (Wong et al., 2016). Donkey's ear abalone (Haliotis asinina Linnaeus, 1758) is a natural biota that shows potential in reducing blood cholesterol. Besides being a source of beneficial omega-3 fatty acids, protein, vitamins, and minerals, abalone also possesses bioactive sulfate polysaccharide, peptides, glycoproteins, chitosan, and carotenoids, identified as compounds with antioxidant, anticoagulant, and antimicrobial effects (Zoysa, 2013). The latest

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Section: Preparation Of Test Animalsmentioning

confidence: 99%

The Potential of Donkey’s Ear Abalone (Haliotis asinina Linnaeus, 1758) as an Antibacterial Agent and Its Effect on Blood Cholesterol Reduction in Mice (Mus musculus Linnaeus, 1758)

2024

JFE

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“…Setelah kering daun diiris kecil-kecil. Sebanyak 200 g daun Harendong Bulu (Clidemia hirta) direbus dengan menggunakan air sebanyak 200 ml, kemudian direbus dengan suhu sekitar 90 0 C selama kurang lebih 15 menit (Shinta & Sudyanto, 2016).…”

Section: Metodeunclassified

“…Setelah diberikan MDLT dan PTU selama 7 hari, selanjutnya Mencit dikelompokkan secara acak untuk diberi perlakuan. Dosis perlakuan air rebusan Clidemia hirta yang digunakan terdiri kelompok P0 = sebagai kontrol tanpa perlakuan diberikan Aquades, kelompok perlakuan P1 = dosis air rebusan 0,13 ml/bb, P2 = dosis air rebusan 0,26 ml/bb, P3 = dosis air rebusan 0,39 ml/bb, dan P4 = dosis simvastatin 0,052 mg/bb (Shinta & Sudyanto, 2016). kemudian mencit diambil sampel darahnya untuk dianalisis kadar kolesterolnya dengan cara memotong bagian ekor mencit tetesan darah pertama dibuang, tetesan berikutnya kemudian diletakkan pada strip dan diukur kadar kolestrol dengan menggunakan alat ukur Autocheck.…”

Section: Metodeunclassified

“…Pemberian air rebusan daun Harendong Bulu (Clidemia hirta) tidak berpengaruh secara signifikan dalam penurunan kadar kolestrol mencit jantan swiss webster. Hal ini bisa saja terjadi karena kesalahan dalam perebusan daun Harendong Bulu (Clidemia hirta) sehingga kemungkinan zat yang berperan dalam penurunan kadar kolestrol hilang atau rusak pada saat perebusan sehingga tidak terdapat pengaruh yang signifikan (Shinta & Sudyanto, 2016). Kondisi seperti ini sering ditemukan dalam proses pengujian suatu obat dimana terjadinya optimalisasi dosis suatu respon farmakologi memiliki efek maksismum pada dosis tertentu (Redha, 2010).…”

Section: Hasil Dan Pembahasanunclassified

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PENGARUH AIR REBUSAN DAUN HARENDONG BULU (Clidemia hirta) TERHADAP KADAR KOLESTROL MENCIT (Mus musculus)

Tuginah¹,

Samitra

Lokaria

2020

Biosilampari

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This study aims to determine the effect of giving boiled water leaves Clidemia hirta on the levels of male webster swiss mice cholesterol. This type of research is an experimental study using the Completely Randomized Design (CRD) method which consists of 5 treatments with 5 repetitions. The experimental animals in this study were male mice which were divided into 5 groups namely P0 (aquadest), P1 (MDLT + PTU + boiled water 0.13 ml/bb), P2 (MDLT + PTU + boiled water 0.26 ml/bb), P3 (MDLT + PTU + boiled water 0.39 ml/bb), and P4 (Simvastatin 10 mg). The treatment was carried out using the gavage method using a gastric sonde device, giving boiled bristle leaves boiled water in the morning for 7 consecutive days carried out in the morning. Retrieval of blood cholesterol levels data by cutting the tail of mice and the next drop blood on the cholesterol strip Autocheck tool. Based on the results of the Kruskal Wallis test calculation states that Hcount <Htable (4.626 <9.49), it can be concluded that the provision of boiled water leaves of Clidemia hirta does no effect significant in reducing levels of male Swiss Webster mice (Mus musculus) cholesterol levels.

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“…Extracts of P. crocatum with many of these ingredients have benefits in various therapeutic activities, including anti-microbial ( Puspita et al, 2019 , Rinanda et al, 2012 ), anti-diabetic ( Nasi et al, 2015 , Safithri and Fahma, 2008 , Shinta and Sudyanto, 2016 ), anti-inflammatory ( Fitriyani et al, 2011 , Laksmitawati et al, 2017 ), and anti-oxidant ( Hendryani et al, 2015 , Tonahi et al, 2014 ). P. crocatum extracts have also been found to have proliferative activity in Baby Hamster Kidney Cell Line 21 (BHK-21) fibroblasts ( Permadi et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Piper crocatum Ruiz & Pav. ameliorates wound healing through p53, E-cadherin and SOD1 pathways on wounded hyperglycemia fibroblasts

Setyawati

Wahyuningsih

Nugrahaningsih

et al. 2021

Saudi Journal of Biological Sciences

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PEMBERIAN AIR REBUSAN DAUN SIRIH MERAH (Piper crocatum Ruiz &Pav) TERHADAP KADAR GLUKOSA DAN KOLESTEROL DARAH MENCIT PUTIH JANTAN

Cited by 4 publications

References 0 publications

The Potential of Donkey’s Ear Abalone (Haliotis asinina Linnaeus, 1758) as an Antibacterial Agent and Its Effect on Blood Cholesterol Reduction in Mice (Mus musculus Linnaeus, 1758)

The Potential of Donkey’s Ear Abalone (Haliotis asinina Linnaeus, 1758) as an Antibacterial Agent and Its Effect on Blood Cholesterol Reduction in Mice (Mus musculus Linnaeus, 1758)

PENGARUH AIR REBUSAN DAUN HARENDONG BULU (Clidemia hirta) TERHADAP KADAR KOLESTROL MENCIT (Mus musculus)

Piper crocatum Ruiz & Pav. ameliorates wound healing through p53, E-cadherin and SOD1 pathways on wounded hyperglycemia fibroblasts

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