Pelvic ultrasound findings in prepubertal girls with precocious adrenarche born appropriate for gestational age

Uçar, Ahmet; Erol, Oğuz Bülent; Yekeler, Ensar; Yıldız, İsmail; Bozlak, Serdar; Saka, Nurçin; Baş, Firdevs; Poyrazoğlu, Şükran; Bundak, Rüveyde; Üzüm, Ayşe Kubat; Gül, Nurdan; Darendelıler, Feyza

doi:10.1111/cen.12355

Cited by 4 publications

(4 citation statements)

References 35 publications

(92 reference statements)

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“…Our results align with this group in that 65% our PA cohort had above lab reference testosterone levels. Uçar et al [28] also demonstrated higher testosterone levels (45.1 pmol/L vs. 31.2 pmol/L, P =0.001) in Turkish girls with PA (n=56) when compared to control girls (n=33) using an RIA assay similar to ours. On the other hand, Paterson et al [27] did not find elevated testosterone in Scottish girls when compared to normal reference range using a chemiluminescent assay (mean+SD [range]).…”

Section: Discussionsupporting

confidence: 84%

“…Since there are many studies that report a high incidence of PCOS in girls with PA, this study attempted to verify if the AMH level is higher in PA girls. One study with Scottish girls reports that the AMH level is higher in PA girls, and 3 studies including this study (Uçar, Utriainen, and this study) report that there is no difference in AML level between the 2 groups [27,28,39]. Two of the 3 studies reporting no difference in AMH levels (Ucar and this study) showed no difference in BMI between the 2 groups, but Utriainen’s study found a significant difference in the BMI between the 2 groups in and compared the AMH level while controlling the BMI.…”

Section: Discussionmentioning

confidence: 67%

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Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Brar

Dingle

Ovadia

et al. 2018

Ann Pediatr Endocrinol Metab

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PurposePremature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls.MethodsRetrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done.ResultsPA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, P<0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups.ConclusionsHigher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 67%

Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Brar

Dingle

Ovadia

et al. 2018

Ann Pediatr Endocrinol Metab

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Section: Discussionmentioning

confidence: 75%

“…In another study from our group, Ucar et al 28 reported that AGA born girls with PA had greater uterine length than their BMI‐matched healthy peers. Although mean ovarian volumes were not significantly different between the groups in that study, decreasing insulin sensitivity was strongly associated with an increase in mean ovarian volume 28 . We could not find any significant association between metabolic parameters and ovarian volumes in this study but, we found a positive association between insulin levels and endometrial thickness.…”

Section: Discussionmentioning

confidence: 75%

Pelvic and breast ultrasound abnormalities and associated metabolic disturbances in girls with premature pubarche due to adrenarche

Aydın

Kadıoğlu²,

Kaya

et al. 2021

Clinical Endocrinology

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Objective Premature adrenarche (PA) has been suggested as a risk factor for future health problems, such as metabolic syndrome and early menarche. However, not all girls with PA have these features and it is not certain who will develop them. We propose that these abnormalities might be identified earlier, even before they are visible. Design Case‐control study. Setting Tertiary care hospital. Participants Forty‐eight girls with premature pubarche due to PA and age (mean age 7.6 ± 1.0 years), weight, body mass index (BMI), birth weight and gestational age‐matched 49 girls with no palpable breast tissue. Measurements Early pubertal pelvic and breast ultrasonographic changes and their associations with obesity and metabolic parameters were evaluated. Blood samples were collected, breast and pelvic ultrasound examinations were performed and bone ages were assessed. Results Girls with PA were taller and their bone ages were higher (p = .049 and p = .005). Fasting blood glucose, insulin, triglycerides, high‐density lipoprotein and low‐density lipoprotein cholesterol were not different between the groups. Luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and estradiol were not different either. Ultrasonography revealed breast gland tissue in 30% of girls with PA and 5% of controls (p = .006). Uterine volume and endometrial thickness were higher in girls with PA (p = .03 and p = .04). Endometrial thickness was positively associated with serum insulin levels in the whole study group and after adjusting for age, diagnosis, BMI, mean ovarian volume and LH, FSH, estradiol levels, this association remained with a borderline p‐value (R2 = 0.486, p = .050). Conclusions We found early changes in uterus and breast glands of girls with PA and endometrial thickness was positively associated with insulin levels.

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Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers

Efthymiadou

Bogiatzidou

Kritikou

et al. 2019

The Journal of Pediatrics

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Pelvic ultrasound findings in prepubertal girls with precocious adrenarche born appropriate for gestational age

Cited by 4 publications

References 35 publications

Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche

Pelvic and breast ultrasound abnormalities and associated metabolic disturbances in girls with premature pubarche due to adrenarche

Anti-Müllerian Hormone in Girls with Premature Adrenarche: The Impact of Polycystic Ovary Syndrome History in their Mothers

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