Pelvic recurrence of an ovarian seromucinous borderline tumor detected by vaginal cytology: A case report and review of the literature

Hayashi, Hironori; Taniguchi, Shuichi; Kurihara, Shuichi; Hachisuga, Kazuhisa; Fukuda, Cassia Tiemi; Inada, Chiaki; Shimao, Yoshiya; Marutsuka, Kousuke; Shimamoto, Tomihiro

doi:10.1002/dc.23525

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…The present case describes rare case of a borderline serous tumor detected by Pap smear. To our knowledge there are only six described cases in literature of SBT detected by Pap smear as the first presentation of the disease (8,14,16,17,18,19) and one case of an ovarian seromucinous borderline tumor recurrence (20). Psammoma bodies were found in five of described SBT cases (8,14,16,18,19), two of them with psammoma bodies only (8,14) and others with abnormal glandular cells like in our case.…”

Section: Discussionsupporting

confidence: 46%

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

et al. 2021

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The Pap test is designed as a screening test to detect primarily carcinoma of the cervix and its precursors, most often of squamous type. Rarely atypical or malignant cells found in cervical smear can be indication for the existence of an extrauterine disease. We present a case of a 26 year old woman with very small asymptomatic ovarian bilateral borderline tumors whose diagnosis was triggered by finding of atypical glandular cells with psammoma bodies on Pap smear. She had a history of abnormal Pap smears and was admitted to our Hospital for colposcopy. Pap smear was taken and reported as atypical glandular cells (AGC) with psammoma bodies. Colposcopically directed biopsy along with an endocervical curettage showed no abnormalities as well as transvaginal ultrasound examination. Three months later control Pap smear confirmed AGC with psammoma bodies (suggestive of endometrial or serous origin), ultrasound showed the presence of indistinctive, hyperechoic mass 2 cm in diameter in the left ovary along with slightly elevated CA-125 and diagnostic hysteroscopy and laparoscopy was performed. At laparascopy, both ovaries had surface cauliflower like papillary projections measuring up to 3 cm. A histological examination revealed bilateral serous borderline tumor.

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Section: Discussionsupporting

confidence: 46%

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

et al. 2021

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“…As mentioned above, the clinical and histological characteristics of SMBT have been previously well described. However, the cytological characteristics of SMBT remain unclear, and only 1 case report of pelvic recurrence has described the cytological findings of SMBT [5]. In this report, the tumor cells of SMBT were observed in a cytological sample of the vaginal stump obtained after radical surgery.…”

Section: Discussionmentioning

confidence: 84%

“…Although the clinical and histopathological characteristics of SMBT are well described in the literature, its cytological characteristics have not been reported. To the best of our knowledge, there is only 1 case report that referred to the cytological findings of SMBT [5]. We recently treated 2 cases of SMBT which were successfully diagnosed by cytological findings of ascites using a combination of immunohistochemistry (IHC) and mucin staining using cell blocks.…”

Section: Introductionmentioning

confidence: 99%

Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases

et al. 2021

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Background: Seromucinous borderline tumor (SMBT) is a rare neoplasm which was newly defined in the 2014 WHO classification. Although the clinical and histopathological characteristics of SMBT have been well described, its cytological characteristics have not. We recently experienced 2 cases of SMBT which were defined by cytological findings of ascites. Case Presentation: Case 1 was a 65-year-old Japanese woman. Preoperative imaging studies revealed abundant ascites and a cystic tumor, with a solid component measuring 13 cm on the left ovary. Radical surgery was performed during the intraoperative diagnosis of ovarian borderline tumor, made by histological examinations of frozen tumor sections. The cytological smears of preoperatively and intraoperatively collected ascites showed many atypical cells resembling reactive mesothelial cells. Alcian-blue staining of cell block sections revealed intracytoplasmic mucin, and the results of immunohistochemistry were consistent with SMBT. The final pathological diagnosis of tumor was SMBT. Case 2 was a 28-year-old Japanese woman. Preoperative imaging studies revealed a small amount of ascites and cystic tumors with solid components in the bilateral ovaries. She initially underwent fertility preservation surgery. SMBT was suspected by cytological examination of smears of intraoperatively collected ascites and the findings of cell block. She underwent additional radical surgery based on a final pathological diagnosis of SMBT. Conclusion: In our experience, the tumor cells of SMBT in ascites mimicked reactive mesothelial cells. The nuclear atypia of SMBTs was intermediate between that of reactive mesothelial cells and serous carcinoma. The immunohistochemistry and mucin staining using cell block were very helpful for facilitating the cytodiagnosis of SMBT.

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“…Numerous neutrophils are commonly observed within the stroma, epithelium, or luminal spaces. Although the low-power architecture closely resembles SBTs, the lining cells are distinctly different, composed of a variety of epithelial In peritoneal fluids, seromucinous tumors will have varying cytomorphologic features, depending largely on the predominant epithelial cell type of the primary lesion [51,52]. The fluid may demonstrate tumor cells with serous, mucinous, endometrioid, clear cell, transitional, or even squamous cell morphology.…”

Section: Seromucinous Neoplasmsmentioning

confidence: 99%

Practical Approach to the Evaluation of Malignant Peritoneal Fluids in the Setting of Gynecologic Neoplasms

Mendoza¹,

Lastra²

2022

Acta Cytologica

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Background: Evaluation of peritoneal fluid cytology, either from ascitic fluids or as result of peritoneal washings, is a fundamental aspect in the evaluation of women presenting with clinically concerning or histologically confirmed gynecologic neoplasms. Summary: Ascitic fluid samples are often the initial and only source of diagnostic material in women presenting with gynecologic malignancies, and important therapeutic decisions will result from the information provided in the cytology report. On the other hand, cytologic evaluation of peritoneal washing specimens obtained during surgical excision of a presumed gynecologic neoplasm provides crucial information to the clinical team regarding tumor staging, often with significant therapeutic implications. While recognition of high-grade tumors in either of these samples is generally straightforward, low-grade tumors and unusual neoplasms can prove to be more difficult to recognize, differentiate from benign mimics, and correctly diagnose, particularly in low-cellularity specimens. Even with high grade tumors, a mere diagnosis of “Positive for malignancy” in diagnostic ascitic fluid specimens might not suffice to guide clinical management, and the use of ancillary techniques to further and more definitively characterize the lesional cells is required. Key Messages: This review will focus on the clinically relevant issues surrounding interpretation of peritoneal fluid cytology specimens in the setting of gynecologic neoplasms, making emphasis on the salient cytomorphologic and immunocytochemical features of the various neoplastic processes, in an attempt to provide a practical yet effective guide on how to best evaluate, diagnose, and report these samples.

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Pelvic recurrence of an ovarian seromucinous borderline tumor detected by vaginal cytology: A case report and review of the literature

Cited by 5 publications

References 17 publications

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

Atypical glandular cells in pap smear as a primarily presentation of ovarian serous borderline tumor

Cytological Appearances of Ovarian Seromucinous Borderline Tumor in Ascites: Presentation of 2 Cases

Practical Approach to the Evaluation of Malignant Peritoneal Fluids in the Setting of Gynecologic Neoplasms

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