Objective The objective benefit of trans-vaginal mesh (TVM) on
the storage function of the bladder in pelvic organ prolapse (POP)
patients waits to be established. This study investigated if TVM
improves the bladder storage by specifically focusing on its effects on
the compliance. Design A retrospective cohort study
Setting A medical center Population Female patients
with voiding dysfunction who underwent TVM for prolapse stage ≥ II (POP
Quantification system) and received urodynamic investigations before and
after the operation. Methods: Data of pressure-flow cystometry
and the derived pressure-volume analysis (PVA) were analyzed.
Main outcome measures Bladder compliance, infused volume, and
threshold pressure. Results Compared with the pre-operative
control, TVM consistently and significantly increased the mean
compliance of the filling stage (Cm; p<0.05 N=22); and further
analyses demonstrated TVM increased the compliance of the late half
(C2/2; p<0.01, N=22), while it exhibited insignificant effects
on that of the early half (C1/2; p>0.05, N=22) of the
filling stage. Moreover, without affecting the infused volume (Vinf;
p>0.05, N=22), TVM decreased the threshold pressure (Pthd;
p<0.01, N=22) and post-voided residual volume (Vres;
p<0.05, N=13). Conclusions TVM improve storage
function of POP patients via increasing bladder compliance, particularly
at the late filling stage for it restored anatomical location and
geometric conformation for bladder expansion. In addition, TVM also
ameliorated voiding dysfunctions as it reduced urine retention, a
symptom could lead to upper urinary tract damage and/or urinary
incontinence.