Pelvic neurofibroma arising from prostate in a case of neurofibromatosis-1

Abstract

Pelvic neurofibroma is a rare condition and can be associated with neurofibromatosis-1 (NF-1). The diagnosis is primarily based on histopathology, though certain characteristic imaging features like the ‘target sign’ on T2W MRI are highly suggestive of the diagnosis. We describe a case of pelvic plexiform neurofibroma in a case of NF-1.

Plexiform neurofibroma masquerading as a seminal vesicle mass: A case review

“…Pelvic PNF is a rare entity, and around 60 cases have been reported so far in the published literature. 2 It usually involves the nerve plexuses near the urinary bladder followed by involvement of the prostate, seminal vesicle and urethra in males and vagina or urethra in females. 5 The majority of these lesions are asymptomatic, and symptoms, if present, are due to the mass effect on adjacent structures or malignant infiltration, which is seen in up to 30% cases of pelvic PNFs.…”

“…PNF has a preponderance for the craniomaxillofacial region, 1 but involvement of the genitourinary tract is rare. 2 The presenting symptoms of PNF mainly depend on the location of the lesion. The pelvic neurofibroma usually presents with lower urinary tract symptoms and bowel dysfunction.…”

Pelvic Neurofibroma

“…Here it shows a presentation with neural pain. Manish et al 1 presented a case of a 12 year old male child with urinary obstruction found to have a prostatic neurofibroma. Nadkarni et al 4 presented case of a 4-year old boy with low-back pain that radiated bilaterally into the L-4 and L-5 dermatomes; intraoperatively, a solid mass, which engulfed the entire cauda equina, could not be dissected from the roots.…”

“…Only 60 cases of pelvic neurofibroma have been reported till date. 1 , 2 We report this case of a pelvic neurofibroma in a 58-year old male, which mimicked a soft tissue tumor on presentation.…”

Mesenchymal tumors of the prostate

“…34,35 Other lesions A variety of other mesenchymal and spindle cell lesions have been reported to occur very rarely in the prostate. These include: angiosarcoma, 56 hemangioma, 57,58 hemangioendothelioma, 59 pleomorphic undifferentiated sarcoma, 60,61 synovial sarcoma, 62 malignant peripheral nerve sheath tumor, 63,64 neurofibroma, 65 and granular cell tumor. 66…”