Pelvic Exenteration for Malignant Melanomas of the Vagina or Urethra with over 3 mm of Invasion

Geisler, John P.; Look, Katherine Y.; Moore, David A.; Sutton, Gregory P.

doi:10.1006/gyno.1995.9966

Cited by 56 publications

(20 citation statements)

References 3 publications

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“…3,5,7 Some authors suggest that radical surgery should be performed due to the more aggressive behavior of vagina melanoma. 8,9 After surgery, patients with a high risk of recurrence (including regional lymph node involvement or thicker primary tumors, i.e. American Joint Committee on Cancer Stage IIb/IIc/ III) should be considered for adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the vagina with repeated local recurrences and brain metastasis

Lin

Liu

Chen

et al. 2011

Journal of the Chinese Medical Association

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Malignant melanoma of the vagina, a very rare malignancy, has a notoriously aggressive behavior associated with a high risk of local recurrence and distant metastasis. At present, there are various treatment options for this disease but no standard guideline. We describe a case of a 54-year-old woman with a locally advanced melanoma of the vagina, who underwent radical surgery, biochemotherapy with interferon-α-2b, chemotherapy, radiotherapy, and repeat excision of local recurrent lesions and brain metastasis. In conclusion, malignant melanoma of the vagina has a high risk for local recurrence. Repeated local excision followed by biochemotherapy is a tolerable treatment.

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Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the vagina with repeated local recurrences and brain metastasis

Lin

Liu

Chen

et al. 2011

Journal of the Chinese Medical Association

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“…Geisler et al advised primary pelvic exenteration for vaginal melanoma over 3 mm of invasion and showed that 50% 5-year survival rate might be obtained if the pelvic nodes were free of metastases [10]. Chung and Ariel, with separate series of 19 and 48 patients, respectively, defend the opinion that the appropriate management of this disease requires radical extirpation of the vagina supplemented by dissection of the regional lymphatics [11,12].…”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Melanoma of the Vagina: Two Cases Reports

Hadiji¹

2013

IOSR-JDMS

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“…Les donné es sont insuffisantes pour é tablir des recommandations. L'amé lioration du contrô le local et de la survie par une chirurgie pelvienne radicale allant jusqu'à l'exenté ration est dé fendue par plusieurs auteurs [16] Toutefois, le bé né fice en termes de survie n'est pas significatif dans les plus grandes sé ries [6][7][8]. La situation est similaire dans le mé lanome ano-rectal.…”

Section: Discussionunclassified