Pelvic Arterial Occlusive Disease Affects the RhoA/Rho-Kinase Pathway in Bladder Smooth Muscle

Akaihata, Hidenori; Nomiya, Masanori; Hata, Junya; Yabe, Michihiro; Takahashi, Norio; Haga, Nobuhiro; Kushida, Nobuhiro; Ishibashi, Keiichiro; Yamaguchi, Osamu; Kojima, Yoshiyuki

doi:10.1016/j.juro.2014.09.102

Cited by 12 publications

(18 citation statements)

References 29 publications

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“…Many studies have shown that Wnt11 and Rock2 protein are closely associated with the development, the invasive capability, and the degree of metastasis for tumors. Studies performed on various cancers, including gastric, liver, colorectal, bladder, prostate, and breast cancer had confirmed the above conclusion [5][6][7][8][9][10]. Within this article is described a study on the role of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of WNT/PCP pathway.…”

Section: Introductionmentioning

confidence: 67%

Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance

Wang

Liu

Zhou

et al. 2016

Pathology - Research and Practice

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Section: Introductionmentioning

confidence: 67%

Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance

Wang

Liu

Zhou

et al. 2016

Pathology - Research and Practice

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“…Zarifpour et al reported that total prostate weights did not differ significantly between control groups and AI groups with local atherosclerosis caused by endothelial injury of the common iliac arteries and a high cholesterol diet. Certainly, we produced the disease model according to their methods . However, we repaired the incisions in the femoral arteries after endothelial injury in the common iliac arteries to avoid ischemia in the lower limbs and preserve blood flow in the lower limbs, whereas the original method ligated the femoral artery after endothelial injury .…”

Section: Discussionmentioning

confidence: 99%

Phosphodiesterase type 5 inhibitor attenuates chronic ischemia‐induced prostatic hyperplasia in a rat model

et al. 2018

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Background Many elderly men suffer from benign prostatic hyperplasia (BPH). Recently, chronic ischemia in the prostate has been suggested to be related to BPH. Thus, the impact of chronic ischemia on the development of prostatic hyperplasia and the efficacy of phosphodiesterase type 5 (PDE5) inhibitor for hyperplasia were evaluated in a rat model with chronic ischemia induced by local atherosclerosis. Methods Eighteen male Sprague‐Dawley rats were divided into three groups: sham operation, regular diet, placebo (SRP); arterial endothelial injury, high cholesterol diet, placebo (AHP); or arterial endothelial injury, high cholesterol diet, and tadalafil as a PDE5 inhibitor (AHT). The endothelial injury in the common iliac arteries was performed using a 2‐Fr Fogarty arterial embolectomy catheter through an incision in the femoral artery into the common iliac artery. Diet and oral drugs were administrated for 8 weeks after surgery. At 8 weeks, blood flow to the ventral prostate (VP) was measured using laser speckle blood flow analysis, and the VP was histologically evaluated. Results In the AHP group, prostatic blood flow was reduced, and mean VP weight and the interstitial area were significantly enlarged compared with the SRP group. In the AHT group, tadalafil administration obviously ameliorated the reduction of prostatic blood flow relative to the AHP group. Importantly, mean VP weight and the morphological changes in the AHT group were significantly smaller than those in the AHP group. Conclusions Enlargement of the VP resulted from chronic ischemia induced by local arteriosclerosis. Also, administration of tadalafil attenuated VP enlargement. Chronic ischemia in the prostate might thus contribute to the development of BPH, and PDE5 inhibitors might provide an innovative approach to preventing BPH.

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“…The focus of attention has currently shifted to the effect of atherosclerosis on the incidence of LUTS . We have already shown the relationship between atherosclerosis and lower urinary tract symptom and/or dysfunction, both in animal studies and in clinical studies . In the animal studies, our group showed that atherosclerosis causes chronic bladder ischemia leading to detrusor overactivity .…”

Section: Discussionmentioning

confidence: 97%

“…18,19 We have already shown the relationship between atherosclerosis and lower urinary tract symptom and/or dysfunction, both in animal studies and in clinical studies. 12,20,21 In the animal studies, our group showed that atherosclerosis causes chronic bladder ischemia leading to detrusor overactivity. 20,21 Also, in the clinical study, we showed that atherosclerosis interfered with the improvement in not only voiding symptoms, but also voiding function after RARP, leading to deterioration of quality of life in the early postoperative period.…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis as a predictor of transient exacerbation of overactive bladder symptoms after robot‐assisted laparoscopic radical prostatectomy

et al. 2018

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Objectives To assess whether atherosclerosis is involved in the development of overactive bladder and the function of lower urinary tract after robot‐assisted radical prostatectomy. Methods The present cohort consisted of 80 consecutive participants. The preoperative cardio‐ankle vascular index was used to evaluate the presence of atherosclerosis. The present cohort was split into two groups, the atherosclerotic group, whose cardio‐ankle vascular index was ≥9.0, and the control group, whose index was <9.0. The overactive bladder symptom score and lower urinary tract function were compared for 12 months after surgery. Results The total score of the questionnaire was significantly higher at 6 and 9 months after surgery in the atherosclerosis group (P = 0.04, P = 0.03, respectively). Both the urgency and urgency incontinence subscores of the questionnaire showed a parallel tendency to that of the total score after surgery. At 3 months after surgery, there was a significant increase in the prevalence of de novo overactive bladder in the atherosclerosis group (P = 0.04). At 9 and 12 months after surgery, there was a significant decrease of voided volume in the atherosclerotic group (P < 0.01, P = 0.04, respectively). Conclusions Atherosclerosis delays the improvement in both overactive bladder symptoms and storage function postoperatively, and it is involved in the transient increase in the prevalence of de novo overactive bladder. Atherosclerosis might be a predictor of the development of overactive bladder after robot‐assisted radical prostatectomy.

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Pelvic Arterial Occlusive Disease Affects the RhoA/Rho-Kinase Pathway in Bladder Smooth Muscle

Abstract: Our results suggest that pelvic arterial occlusive disease can affect the RhoA/Rho-kinase pathway in the bladder. This pathway might possibly be involved in the maintenance of tonic contraction and contribute to the bladder hyperactivity caused by pelvic arterial occlusive disease.

Cited by 12 publications

References 29 publications

Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance

Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance

Phosphodiesterase type 5 inhibitor attenuates chronic ischemia‐induced prostatic hyperplasia in a rat model

Atherosclerosis as a predictor of transient exacerbation of overactive bladder symptoms after robot‐assisted laparoscopic radical prostatectomy

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