Pelvic angiomyofibroblastoma: an unusual case report

Abstract

Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to middle-aged women, arising from the genital tract. There are many overlapping radiological and immunohistochemical features with other stromal cell lesions, making the diagnosis difficult. We report here a case of a 29-year-old woman admitted for a pelvic mass, in whom, the histopathological and immunohistochemical studies led to the diagnosis of angiomyofibroblastoma.

Angiomyofibroblastoma and Potential Mimicking Soft Tissue Tumors That May Occasionally Present in the Retroperitoneum: An Approach to the Differential Diagnosis With Report of an Unusual Index Case Abutting the Kidney

“…Generally, AMFB presents as a painless superficial mass in the vagina or vulva 2. Origin in nonvulvovaginal sites is rare but well recognized3–25 (Table 2) and may be associated with unexpected clinical presentations, as in a patient who developed dysuria secondary to a urethral AMFB,4 and in our patient, who was felt to have a primary kidney tumor.…”

“…AMFB is an uncommon, benign mesenchymal tumor first described by Fletcher et al2 in a series of 10 cases that occurred exclusively in the vulvovaginal region of premenopausal women. Infrequent cases from nonvulvovaginal sites have been reported in the fallopian tube, cervix, urethra and bladder3–13 and, even more rarely, in the pelvis14,15 and retroperitoneum1 (Table 2). 3–25 Similar but distinct tumors, designated as AMFB-like tumor and, subsequently, cellular angiofibroma may also be found in the inguinoscrotal region of men26,27 and are considered separately below.…”