Pellagra‐like erythema on sun‐exposed skin of patients with anorexia nervosa

Sato, Mitsuyoshi; Matsumura, Yasuhiro; Kojima, Ayako; Nakashima, Chisa; Katoh, Mayumi; Kore-Eda, Satoshi

doi:10.1111/j.1346-8138.2010.01164.x

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…Because our animal pellagra model involves photosensitivity dermatitis, it is especially useful for the analysis of its pathogenesis. Consistent with findings in human pellagra15, we demonstrate that UVB-induced skin inflammation is enhanced and prolonged in C57BL/6 mice treated with the niacin antagonist 6-AN. Consistently, the histology findings in these mice were fundamentally the same as those found in human pellagra15.…”

Section: Discussionsupporting

confidence: 89%

“…Consistent with findings in human pellagra15, we demonstrate that UVB-induced skin inflammation is enhanced and prolonged in C57BL/6 mice treated with the niacin antagonist 6-AN. Consistently, the histology findings in these mice were fundamentally the same as those found in human pellagra15. In addition, we demonstrated that COX-2 ( Ptgs2 ) expression was enhanced in 6-AN-induced photosensitivity, and that the photosensitivity was attenuated by a COX inhibitor indomethacin.…”

Section: Discussionsupporting

confidence: 89%

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Prostaglandin E2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

Sugita

Ikenouchi-Sugita

Nakayama

et al. 2013

Sci Rep

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Pellagra is a photosensitivity syndrome characterized by three “D's”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE2 production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Prostaglandin E2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

Sugita

Ikenouchi-Sugita

Nakayama

et al. 2013

Sci Rep

Self Cite

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“…Alcoholic liver disease which is present in half of alcohol dependent population also contributes to cutaneous findings 6 . Poor diet, malabsorption of Pyridoxine and thiamine deficiency further contribute to it 7 . Although outbreaks of Pellagra are common during crisis in developing countries but diagnosis is scarce and may be mistaken for vast array of diseases as the presentation often varies.…”

Section: Discussionmentioning

confidence: 99%

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

Shaz,

Shilpa,

Mohan

2023

JCBS

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Alcoholism a chronic condition affects multiple organ systems including skin. Dermatological markers of alcohol abuse are invaluable. Despite this, association of skin diseases and alcohol misuse maybe overlooked or physicians fail to explore. Pellagra is a multifactorial disease caused by Niacin/Tryptophan deficiency. It exhibits photodermatitis, gastrointestinal and neuropsychiatric manifestations. Chronic alcoholics are at risk. Considering pellagra as differential diagnosis in chronic alcoholics with these symptoms is crucial. This disease is easily treatable but if missed proves fatal. Hence, its recognition is important in other clinical settings for comprehensive treatment. The pathognomonic presentation of Pellagra is the Casal necklace, but here we present a case of 34year old alcoholic with an atypical presentation of Pellagra. Chronic alcoholics need evaluation for Pellagra amongst other nutritional deficiencies which due to diverse presentation can be missed. Early diagnosis and treatment can avoid impending neuropsychiatric complications. Due to participation of numerous disciplines consultation liaison psychiatry is vital here. Keywords: Alcohol dependence, Alcohol cutaneous manifestations, Pellagra, Niacin deficiency, Alcohol biomarkers

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“…In jowar, niacin is unbound but large quantities of leucine interfere with the conversion of tryptophan to niacin. Dietary deficiency of niacin can occur in anorexia nervosa, [4] food faddism, and malabsorption syndromes, and Hartnup disease, [5] In carcinoid syndrome, deficiency occurs due to the excessive conversion of tryptophan to serotonin. [6] Common drugs causing pellagra are isoniazid (INH), pyrazinamide, [5] fluorouracil, [6] mercaptopurine azathioprine, [7] and anticonvulsants.…”

Section: Figure 1: Pellagra Lesions On Handsmentioning

confidence: 99%

A case of alcohol-dependent syndrome and pellagra

Ambika

Chankramath

Prathyusha

2013

Int J Nutr Pharmacol Neurol Dis

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Pellagra was first described by Casal in 1735 as a disease due to the deficiency of niacin. Pellagra is more common in alcoholics. Chronic alcoholism and smoking are not uncommon in females of rural India. We report a case of a middle-aged female presenting with alcohol-dependent syndrome and pellagra. New features on the journal's websiteOptimized content for mobile and hand-held devices HTML pages have been optimized for mobile and other hand-held devices (such as iPad, Kindle, iPod) for faster browsing speed. Click on [Mobile Full text] from Table of Contents page. This is simple HTML version for faster download on mobiles (if viewed on desktop, it will be automatically redirected to full HTML version)

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Pellagra‐like erythema on sun‐exposed skin of patients with anorexia nervosa

Cited by 9 publications

References 8 publications

Prostaglandin E2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

Prostaglandin E2 is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

The Guard, His Gauntlet and Goblet- An Atypical Presentation of Pellagra in a Chronic Alcoholic

A case of alcohol-dependent syndrome and pellagra

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