Peliosis Lienis: Uncommon Cause of Rupture of the Spleen

Gabor, S; Back, F.; Csiffáry, D

doi:10.1016/s0344-0338(11)81227-6

Cited by 19 publications

(17 citation statements)

References 8 publications

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“…Peliosis has been Forensic Science International 149 (2005) [25][26][27][28][29][30][31][32][33] related to several underlying debilitating illnesses or medications, and different theories have been proposed concerning the pathogenesis of this unique disorder over the years. While some investigators favour congenital malformation of vessels or microcirculatory disturbances manifesting under altered local intravascular pressure conditions as responsible for the development of the disease [4,[8][9][10], others believe that an acquired vascular disorder triggered by toxic noxae may play a key role in the pathogenesis [11,12]. However, none of the chronic or toxic conditions previously described in association with peliosis or the pathogenetic mechanisms they may induce can satisfactorily explain the pathological findings in all cases and organs involved, respectively, and the morphological data obtained by different investigators suggest that there is more than one path of formal pathogenesis to the onset and maintenance of peliosis.…”

Section: Introductionmentioning

confidence: 99%

Pathology of peliosis

Tsokos

Erbersdobler

2005

Forensic Science International

162

106

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Section: Introductionmentioning

confidence: 99%

Pathology of peliosis

Tsokos

Erbersdobler

2005

Forensic Science International

162

106

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“…15 The clinical significance of this differentiation lies in the potential of peliotic lesions to rupture and cause life-threatening intraperitoneal hemorrhage. [2][3][4]6,9,[16][17][18][19] Due to the risk of rupture, needle biopsy of a suspected peliotic lesion is illadvised and further enhances the need for sensitive radiological tests. On ultrasound, peliotic lesions may be hypo-echoic or hyperechoic lesions without sharply demarcated borders.…”

Section: Discussionmentioning

confidence: 99%

'Not just another appendicitis!' – a case report of acute abdominal pain caused by splenic rupture secondary to isolated splenic peliosis

Qureshi

Choong²,

Tadrous³

et al. 2009

Ann R Coll Surg Engl

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Case historyA previously healthy 31-year-old Polish male presented to the accident and emergency department with suddenonset of abdominal pain. The pain followed an alcohol binge 8 h prior to his presentation and was generalised and constant in nature. There was no history of trauma related to his excessive alcohol intake. There was one episode of vomiting but no other bowel or urinary symptoms. He also complained of pain in his left shoulder.On physical examination, the abdomen was soft and non-distended. Tenderness was elicited all over the abdomen but was more severe in the epigastric region and right loin with mild guarding. There was no rebound tenderness or rigidity. There were no masses or organomegaly to find. He was afebrile and no abnormalities were detected in the cardiovascular and respiratory examinations. His blood pressure was 130/85 mmHg and heart rate was 83 bpm.Laboratory tests demonstrated a raised white blood cell count of 13.7 × 10 9 /l (normal range, 4.5-11.0 × 10 9 /l) and a C-reactive protein of 16 mg/l (normal range, 0-8 mg/l). Renal, liver function tests, serum amylase and clotting profile were all within normal limits. An erect chest and abdominal radiograph did not reveal any abnormalities. Abdominal ultrasound showed a large amount of abdominopelvic free fluid. The liver was normal in echoic texture with no focal lesions, and the pancreas and kidneys were also normal. The spleen was 'Not just another appendicitis!' -a case report of acute abdominal pain caused by splenic rupture secondary to isolated splenic peliosis ABSTRACTWe present the case of a 31-year-old man admitted with acute abdominal pain who was subsequently found to have a ruptured spleen. A splenectomy was performed as an emergency and he was discharged from hospital 4 days later. Histological analysis revealed isolated splenic peliosis as the underlying condition predisposing to his splenic rupture.

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“…The clinical significance of splenic peliosis lies in the potential for intraperitoneal hemorrhage following rupture of a lesion [4][5][6]. Some fatal cases have been reported, but, to our knowledge, there are only two previous reports on splenic rupture with intraperitoneal hemorrhage secondary to splenic peliosis that was diagnosed before surgical exploration [5,6].…”

Section: Discussionmentioning

confidence: 99%