Peliosis Hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes

Tsirigotis, Panagiotis; Sella, Tal; Shapira, M Y; Bitan, Menachem; Bloom, Allan I.; Kiselgoff, David; Levin, Mark; Libster, Dianna; Hai, Abdul; Gesundheit, Benjamin; Or, R.; Slavin, S; Resnick, Igor B.

doi:10.3324/haematol.11343

Cited by 42 publications

(21 citation statements)

References 22 publications

(21 reference statements)

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“…Unlike OCs, anabolic androgen steroids have been mainly associated with peliosis, while SD was only mentioned as the initial lesion, with no predominance in any specific area . Indications for steroids include stimulation of hematopoiesis, female transexuality, male impotence, and bodybuilding . None of these underlying conditions have been associated with peliosis.…”

Section: Conditions Associated With Sdmentioning

confidence: 99%

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

et al. 2015

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Sinusoidal dilatation found in the absence of an impaired sinusoidal blood outflow has been so far of unclear significance. Sinusoidal dilatation may actually be a nonspecific feature of impaired portal venous blood inflow, whatever the cause, or a feature of severe systemic inflammatory reaction syndrome, whatever the cause. Sinusoidal dilatation is mainly located in the centrilobular area even in the absence of an outflow block. A predominantly periportal location is specifically found in oral contraceptive users, associated with an inflammatory condition. There is strong evidence for the association of sinusoidal dilatation and oxaliplatin-based chemotherapy but not for estroprogestative steroids or thiopurine derivatives. Exposure to anabolic androgen steroids appears to cause sinusoidal changes different from a mere sinusoidal dilatation. Conclusion: There is evidence of activation of the interleukin-6 and vascular endothelial growth factor pathways in sinusoidal dilatation, but the mechanisms linking the activation of these pathways with the microvascular changes must be identified. (HEPATOLOGY 2015;62:956-963) S inusoidal dilatation (SD) in the absence of postsinusoidal outflow block is characterized by enlarged hepatic sinusoids as a predominant histopathological feature.

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Section: Conditions Associated With Sdmentioning

confidence: 99%

The significance of nonobstructive sinusoidal dilatation of the liver: Impaired portal perfusion or inflammatory reaction syndrome

et al. 2015

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“…This phenomenon most commonly is associated with androgens105 or contraceptive steroids 106. Thiopurine-derived chemotherapeutic drugs also have been implicated 107 108.…”

Section: Vascular Abnormalitiesmentioning

confidence: 99%

Histological patterns in drug-induced liver disease

2009

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“…6 Tóth et al 7 reported a patient with hepatic peliosisinduced hemoperitoneum who was treated with embolization which was performed by superselective catheterization of the left hepatic artery to stop the bleeding and then left lobectomy of the liver was performed. Tsirigotis et al 8 also reported one patient with peliosis hepatis who developed severe subcapsular bleeding and was treated with catheterization of the right hepatic artery and embolization.…”

Section: Discussionmentioning

confidence: 99%