Peliod Hepatocellular Carcinoma in a Domesticated Ferret (<i>Mustela Putorius Furo</i>)

Jones, Yava L.; Wise, Annabel G.; Maes, Roger K.; Kiupel, Matti

doi:10.1177/104063870601800219

Cited by 10 publications

(7 citation statements)

References 15 publications

(19 reference statements)

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“…In HCC, approximately 40% of HCCs with high histological grade also had PC as we previously reported . Immunohistochemical staining for cytokeratin 8 or 18 and endothelial cell markers such as CD31, CD34, factor VIII, and von Willebrand factor have been shown to be useful for distinguishing PHCC from vascular neoplasms occurring in the liver such as hemangioma or angiosarcoma …”

Section: Discussionsupporting

confidence: 56%

Clinicopathologic analysis of the simple nodular type of well‐differentiated hepatocellular carcinoma with extensive peliotic change

Nomura

Nakashima

Kumabe

et al. 2014

J of Gastro and Hepatol

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Background and Aim Peliosis hepatis‐like blood‐filled cavities are frequently observed in hepatocellular carcinoma (HCC). Peliotic change (PC) is commonly seen in moderately differentiated HCCs and rarely in well‐differentiated HCCs. We conducted clinicopathological analysis of well‐differentiated HCC with PC (PHCC). Methods A total of 1225 patients underwent hepatectomy at Kurume University Hospital between 1992 and 2010. Of these, 101 cases were diagnosed as well‐differentiated HCC. Immunohistochemical double staining of CD34 and α smooth muscle actin was performed to examine the number and diameter of arterial blood vessels and drainage veins around tumors. We compared the clinical manifestations, histopathological features, and imaging findings of these cases. Results Seven cases of 101 well‐differentiated HCCs had PC. Almost of PHCCs were macroscopically classified as the simple nodular type with a fibrous capsule, and microscopically showed thin trabecular arrangement of tumor cells and extensive dilated sinusoid‐like structures filled with red blood cells. The number of arteries inside the tumor was significantly higher in PHCCs than in the simple nodular type of well‐differentiated HCCs without PC. Furthermore, no significant differences were observed in the ratio of the number of irregularly shaped drainage veins around the tumor to the tumor diameter. Imaging revealed that most of the tumors had capsule‐like structures and showed prolonged enhancement in the delayed phase of dynamic study of imagings. Conclusion PC is unusually observed in well‐differentiated HCC and the size of PHCC was larger than that of well‐differentiated HCC without PC and most are detected as a hypervascular tumor on images.

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Section: Discussionsupporting

confidence: 56%

Clinicopathologic analysis of the simple nodular type of well‐differentiated hepatocellular carcinoma with extensive peliotic change

Nomura

Nakashima

Kumabe

et al. 2014

J of Gastro and Hepatol

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“…The most common disorders of the ferret biliary system are the presence of benign biliary cysts and metastatic adrenal tumours (Burgess 2007). Biliary duct adenoma, carcinoma, cystadenoma and cystadenocarcinoma have also been reported, but are uncommon (Reindel and Evans 1987, Garcia and others 2002, Jones and others 2006). Extrahepatic bile duct obstruction (EHBO) and gall bladder mucocele are well‐recognised syndromes in cats and dogs (Mayhew and others 2002).…”

Section: Introductionmentioning

confidence: 99%

Extrahepatic biliary tract obstruction in two ferrets (Mustela putorius furo)

Hauptman

Jekl

Knotek³

2011

Journal of Small Animal Practice

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This report describes extrahepatic bile duct obstruction in two ferrets, which were presented with anorexia, chronic weight loss and general weakness. Physical examination revealed lethargy, cachexia, dehydration, abdominal pain and icterus. Marked haematological, serum chemistry and urinalysis abnormalities included hyperbilirubinaemia (65·5 and 114·2 μmol/L), high concentrations of alanine transaminase (1327·53 and 2578·88 IU/L) and biluribinuria. Abdominal ultrasonography revealed thickening of the bile duct together with the gall bladder wall. The common bile duct was obviously distended. Choledochotomy revealed inspissated bile with fragile green gelatinous plugs that was removed to allow the bile to flow into the duodenum. Cytology and culture of the biliary tract contents were negative for bacteria. Laboratory analyses of biliary plugs showed presence of only protein substances, without detectable mineral composition. Histopathological examination of the liver showed diffuse steatosis and non-specific cholangiohepatitis in both cases.

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“…Immunohistochemical analysis was necessary to differentiate hepatocellular neoplasia from vascular neoplasm, such as hemangiosarcoma. 88 Concurrent adrenocortical hyperplasia was observed in this case and the investigatord speculated about a possible association. 88 Hepatic carcinoma generally results in increased concentration of hepatic enzyme.…”

Section: Hepatic Carcinomamentioning

confidence: 66%

“…One case of peliod hepatocellular carcinoma was diagnosed in a ferret. 88 The left medial liver lobe was affected with a 12-cm diameter mass. The mass had rubbery-to-soft consistency and had completely effaced normal hepatic parenchyma.…”

Section: Hepatic Carcinomamentioning

confidence: 99%

Diagnosis of Liver Disease in Domestic Ferrets (Mustela Putorius)

Huynh

Laloi

2013

Veterinary Clinics of North America: Exotic Animal Practice

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Liver disease in ferrets is often subclinical and underdiagnosed. Clinical pathology and diagnostic imaging are needed to guide clinicians but definite diagnosis is based on histopathologic lesions. Inflammatory digestive conditions can lead to ascending tract infection and hepatobiliary inflammation. Ferrets have a specific sensitivity to hepatic lipidosis. Incidence of hepatic neoplasia is high in ferrets. After a summary of anatomy and physiology of the ferret liver, hepatic diseases known in ferret species are reviewed with their subsequent diagnostic procedures.

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Peliod Hepatocellular Carcinoma in a Domesticated Ferret (Mustela Putorius Furo)

Cited by 10 publications

References 15 publications

Clinicopathologic analysis of the simple nodular type of well‐differentiated hepatocellular carcinoma with extensive peliotic change

Clinicopathologic analysis of the simple nodular type of well‐differentiated hepatocellular carcinoma with extensive peliotic change

Extrahepatic biliary tract obstruction in two ferrets (Mustela putorius furo)

Diagnosis of Liver Disease in Domestic Ferrets (Mustela Putorius)

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