Pelargonidin inhibits vascularization and metastasis of brain gliomas by blocking the PI3K/AKT/mTOR pathway

Nano-pelargonidin modulates p53/PARP/HSP 90/XRCC1 signaling axis to combat cypermethrin-induced genotoxicity and metabolic dysfunction in fish: a molecular docking predicted in vivo approach

“…37–39 They have been shown to have powerful biological actions against stress and its related damage in biological macromolecules, such as DNA breakage, protein expression modification, and tissue obliteration. The phytocompound pelargonidin (PG), a natural anthocyanidin, has been reported to exhibit vaso-protective, 40 anti-inflammatory, 41 anti-carcinogenic, 42 anti-obesity, 43 and anti-diabetic 44,45 activities by rescuing cells and tissues from cytotoxicity and genotoxicity caused by several toxicants, both in its phytochemical form and nano-encapsulated forms. 16–49 On the other hand, several toxicological investigations of xenobiotics have found a correlation with the impairment of key DNA repair proteins, such as p53, PARP, HSP 90, and XRCC1, which promote dysfunction of signalling cascades and ultimately lead to genetic instability.…”

“…The phytocompound pelargonidin (PG), a natural anthocyanidin, has been reported to exhibit vaso-protective, 40 anti-inflammatory, 41 anti-carcinogenic, 42 anti-obesity, 43 and anti-diabetic 44,45 activities by rescuing cells and tissues from cytotoxicity and genotoxicity caused by several toxicants, both in its phytochemical form and nano-encapsulated forms. 16–49 On the other hand, several toxicological investigations of xenobiotics have found a correlation with the impairment of key DNA repair proteins, such as p53, PARP, HSP 90, and XRCC1, which promote dysfunction of signalling cascades and ultimately lead to genetic instability. 18,24,33,39 Therefore, an approach based on nanotechnology was exploited in the present study to address the issue of cypermethrin (CM) pesticide-induced genotoxicity in a tilapia fish model, whereby the phytocompound PG was encapsulated in PLGA to check whether the formulated nano-pelargonidin (NPG) would play a beneficial role in inhibiting the progression and intense complications that may develop in fish when exposed to the toxic chemical pesticide CM.…”