PEI functionalized cell membrane for tumor targeted and glutathione responsive gene delivery

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

“…Dendritic polymers good absorption and bioavailability, easy surface modifications [11], low toxicity, non-immunogenic and good pharmacokinetics [12] complex arrangements, special reaction difficulties, and cationic dendritic polymers often exhibit high toxicity [11] PLGA nanocarriers biodegradable, biocompatible, slow-releasing [13] poor binding of negatively charged drugs, rapidly cleared in vivo, unable to recognize cells, not selective [14,15] PEI excellent biocompatibility and high transfection efficiency [13] potential cytotoxicity following intracellular accumulation [16] Magnetic nanoparticles superparamagnetic, reduces the distribution of cytotoxic substances in cells, and increases cellular uptake at targeted sites [17] poor biocompatibility, hydrophobic surface, large specific surface area prone to cluster formation and thus embolization [17] AuNPs easy surface modification, size and shape control, photothermal effect, enhanced cellular uptake, increased drug toxicity, tumor growth inhibition, and selective drug targeting [18] surface-dependent toxicity, poor stability under physiological conditions [19,20] Mesoporous silica nanoparticles highly biocompatible, controllable shape and size, allows for effective drug accumulation, improved drug stability and solubility [21] not easy to store; restrictive drug loading; drug interactions in the mesoporous lumen [21] Liposome targeting tumors, promoting the mobility and durability of anticancer drugs, and improving pharmacokinetic and pharmacodynamic profiles of chemotherapeutic agents [9] poor stability, low solubility, multidrug resistance, payload leakage, and phospholipid oxidation [22,23] Carbon nanotubes enhanced electrical conductivity and strength, easy to functionalize, easy to be absorbed by a variety of cells, unique optical properties can improve phototherapy [24] non-biodegradable, poorly dispersed, and prone to aggregation and cytotoxicity [24] Gold nanoparticles (AuNPs) have gained attention in the field of drug delivery due to their superior properties compared to liposomes, polymers, dendrimers, and metal nanoparticles [25]. These properties include good biocompatibility, a large specific surface area, surface modifiability, and excellent stability and dispersion characteristics [26].…”