PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo : A quantitative study using radiolabeling and positron emission tomography

Fluorophore Labeling of Core-Crosslinked Polymeric Micelles for Multimodal In Vivo and Ex Vivo Optical Imaging

“…The liver uptake of the iCCPM was found to be ~20% at 48 h p.i., which corresponds with previous reports, and results from clearance by the mononuclear phagocytic system (MPS). [54][55][56][57] In addition, a relatively prominent kidney accumulation was observed (~20% of the injection dose at 1 h). At early time points, also localization in bladder could be detected (~10% ID at 1 h), indicating that part of the labeled polymers were excreted renally.…”

“…Retention of the signal in kidney at later time points during follow-up is in line with this notion, as drug-and/or targeting ligandmodified macromolecular nanocarriers progressively accumulate in the kidney over time. [19,[54][55][56][57][58] This likely results from the initial glomeral filtration of polymeric nanocarrier materials with a size below ~45 kDa, followed by their (unspecific) retention in brush border membranes in the kidney.…”

Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: Probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation

“…It was concluded that the peg coating density hold a significant impact on the biodistribution of nanoparticles. For instance, pegylation of HPMA-based block copolymers enhanced tumor accumulation in vivo, starting from the lowest tumor uptake for the pure block copolymer to highest accumulation with 11% PEG side chains [59]. Various amounts of PEG were also conjugated to linoleic acid and poly(β-malic acid) double grafted chitosan (LMC) NPs with similar ligand density of folate (FA), and FA-LMC NPs with moderate PEG grafting density (8.9%) out-performed other FA-LMC NPs in terms of in vivo antitumor efficacy [60].…”

Radiolabeling of Nanoparticles and Polymers for PET Imaging

“…In spite of all these benefits, in the clinics, 18 F is mostly used in the form of 2-[ 18 F]fluoro-2-deoxy- d -glucose ([ 18 F]FDG). Recently, 18 F has been used as a suitable PET nuclide to track NPs, quantum dots (QDs) or polymers, in vivo [4,15,16,17,18,19,20,21,22,23,24]. Section 2 will give a short overview of the research carried out using 18 F-labeling in combination with polymers and NPs and their most important characteristics.…”