PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery

Xiao, Yunxin; Liu, Qingtao; Clulow, Andrew J.; Tang, Li; Manohar, Madhura; Gilbert, Elliot P.; Campo, Liliana de; Hawley, Adrian; Boyd, Ben J.

doi:10.1016/j.colsurfb.2019.110362

Cited by 25 publications

(16 citation statements)

References 78 publications

(103 reference statements)

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“…In addition to PEGylation and size alteration, liposomes can also be functionalized by attaching certain chemistry functional groups, peptides, antibodies, or acids to their surface to improve cell targeting efficiency [55,60]. Similar to the antigen-antibody complex formed between the antibody conjugated to the nanoparticles and the antigen presented on the surface of the cell, chemistry functional groups conjugated to the surface of the nanoparticles can form strong covalent bonds with metabolically labelled cell surface glycans [60]. Such reaction is known as "click" chemistry [60].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

“…Similar to the antigen-antibody complex formed between the antibody conjugated to the nanoparticles and the antigen presented on the surface of the cell, chemistry functional groups conjugated to the surface of the nanoparticles can form strong covalent bonds with metabolically labelled cell surface glycans [60]. Such reaction is known as "click" chemistry [60]. Compared with antigen-antibody complex, the "click" chemistry requires fewer functional groups, and form stronger bonds to allow sufficient time for the encapsulated nano-drugs to be internalized into the cells [60].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

“…Such reaction is known as "click" chemistry [60]. Compared with antigen-antibody complex, the "click" chemistry requires fewer functional groups, and form stronger bonds to allow sufficient time for the encapsulated nano-drugs to be internalized into the cells [60]. Recently, Boyd's groups functionalized liposomes containing drug nanocrystals using PEGylation and attachment of azide functional groups to improve drug loading capacity and to achieve cell-targeted delivery [60].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

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Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

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Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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“…The modification of PEG on the liposomes prolonged the circulation time via avoiding rapid uptake by the reticuloendothelial system (RES). 44…”

Section: The Protective Effect Of Tf-ost-lip In Vitromentioning

confidence: 99%

<p>Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice</p>

Kong

et al. 2020

IJN

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Introduction: Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of Alzheimer's disease (AD). However, the effectiveness of the drug is limited by its solubility and bioavailability, as well as by the low permeability of the bloodbrain barrier (BBB). In this study, a kind of transferrin-modified Ost liposomes (Tf-Ost-Lip) was constructed, which could improve the bioavailability and enhance brain targeting. Methods: Tf-Ost-Lip was prepared by thin-film hydration method. The ability of liposomal formulations to translocate across BBB was investigated using in vitro BBB model. And the protective effect of Tf-Ost-Lip was evaluated in APP-SH-SY5Y cells. In addition, we performed pharmacokinetics study and brain tissue distribution analysis of liposomal formulations in vivo. We also observed the neuroprotective effect of the varying formulations in APP/PS-1 mice. Results: In vitro studies reveal that Tf-Ost-Lip could increase the intracellular uptake of hCMEC/D3 cells and APP-SH-SY5Y cells, and increase the drug concentration across the BBB. Additionally, Tf-Ost-Lip was found to exert a protective effect on APP-SH-SY5Y cells. In vivo studies of pharmacokinetics and the Ost distribution in brain tissue indicate that Tf-Ost-Lip prolonged the cycle time in mice and increased the accumulation of Ost in the brain. Furthermore, Tf-Ost-Lip was also found to enhance the effect of Ost on the alleviation of Alzheimer's disease-related pathology. Conclusion: Transferrin-modified liposomes for delivery of Ost has great potential for AD treatment.

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“…Several studies shown the drug‐loaded on a nanocarrier has greater efficiency than the free drug 1‐4 . The performances of nanocarriers can be further enhanced through surface modification using several functional groups 5‐8 …”

Section: Introductionmentioning

confidence: 99%

Design of new drug delivery platform based on surface functionalization of black phosphorus nanosheet with a smart polymer for enhancing the efficiency of doxorubicin in the treatment of cancer

Hashemzadeh

Raissi

2021

J Biomedical Materials Res

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The development of drug delivery systems (DDSs) has raised hopes for targeted cancer therapy. Smart polymers can be conjugated with several nanoparticles and increase their efficiency in biomedical applications. In this work, the classical molecular dynamics and well‐tempered metadynamics simulations are performed to study the behavior of black phosphorus (BPH) nanosheet functionalized with polyethylenimine (PEI) in adsorption, diffusion, and release of doxorubicin (DOX) anticancer drug. Adsorption of the drug on PEI‐BPH surface is mainly due to the formation of strong pi–pi interaction between the drug and BPH. The drug‐binding to the nanosheet is enhanced by the intermolecular hydrogen bond that formed between DOX and PEI. The energy values for the interaction of DOX with BPH and PEI are calculated to be about − 180 and − 50 kJ/mol, respectively. The obtained results indicated that the adsorption of the drug molecules on the nanosheet destroyed the hydration layer around the BPH‐PEI surface. The free energy calculation for DDS shows a global minimum in which the distances of DOX from BPH surface and PEI are about 1.0 and 0.5 nm, respectively. Furthermore, the diffusion of DDS into the membrane has a macropinocytosis pathway that is in line with experimental observations. Moreover, it is found that, unlike the isolated DOX, the drug in complex with BPH‐PEI can be easily penetrated membrane cells. The study of the pH‐responsive release of the drug shows the high solubility of the polymer in the water environment plays the main role in swelling of DDS and the release of the DOX molecules.

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PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery

Cited by 25 publications

References 78 publications

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

<p>Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice</p>

Design of new drug delivery platform based on surface functionalization of black phosphorus nanosheet with a smart polymer for enhancing the efficiency of doxorubicin in the treatment of cancer

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