PEGylation and preliminary biocompatibility evaluation of magnetite–silica nanocomposites obtained by high energy ball milling

Pilloni, Martina; Nicolas, Julien; Marsaud, Véronique; Bouchemal, Kawthar; Frongia, Francesca; Scano, Alessandra; Ennas, Guido; Dubernet, Catherine

doi:10.1016/j.ijpharm.2010.09.010

Cited by 31 publications

(16 citation statements)

References 54 publications

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“…It is worth to mention that poly(ethylene glycol) (PEG) is one of the polymers most commonly employed in nano-biomedicine, due to its biocompatibility and steric repulsion features. It is possible to find in the literature many different ways under which PEG can be bound onto magnetic nanoparticles, to mention a few: sol-gel technique (Gupta et al, 2007), polymerization in the presence of nanoparticles (Flesch et al, 2005), implantation of silane groups on the surface of the nanoparticles (Pilloni et al, 2010) among others. Besides PEG, dextran is another candidate largely used as surface modifying agent.…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…Though most studies indicate that these particles do not cause biocompatibility problems in the short term, the effects of chronic exposure have not been adequately studied [30–33]. PEGylation reduces the toxicity of nanoparticles by minimizing the interaction between the high energy nanoparticle surface and the cell membrane, which can lead to disruption of the lipid bilayer [34]. Organic nanoparticles, such as liposomes, micelles and polymersomes, are much more readily degraded in the body, making chronic toxicity less of a concern.…”

Section: Circulation and Tumor Targetingmentioning

confidence: 99%

Odyssey of a cancer nanoparticle: From injection site to site of action

Nichols¹,

Bae²

2012

Nano Today

320

275

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No chemotherapeutic drug can be effective until it is delivered to its target site. Nano-sized drug carriers are designed to transport therapeutic or diagnostic materials from the point of administration to the drug’s site of action. This task requires the nanoparticle carrying the drug to complete a journey from the injection site to the site of action. The journey begins with the injection of the drug carrier into the bloodstream and continues through stages of circulation, extravasation, accumulation, distribution, endocytosis, endosomal escape, intracellular localization and—finally—action. Effective nanoparticle design should consider all of these stages to maximize drug delivery to the entire tumor and effectiveness of the treatment.

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“…A "solid state method", specifically high energy ball milling (HEBM), is a novel approach to obtain nanometer-sized materials (Pilloni et al 2010). HEBM has been found to be suitable for a variety of other materials (Abdul Khalil et al 2011) but was originally developed in the 1970's as an industrial process to effectively produce composites and new alloys (Kong et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Fire Retardant Nano-Filler from Oil Palm Empty Fruit Bunch Fibers

Saba¹,

Paridah²,

Abdan³

et al. 2015

BioResources

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The possibilities of utilizing an abundantly available agricultural waste, oil palm empty fruit bunch (OPEFB) fibers, for the development of nano-filler was investigated. The aim was to develop fire retardant nano-fillers from OPEFB fiber through grinding, chemical treatment (bromine water and SnCl2), and cryogenic crushing, followed by a high energy ball milling process. The structural, morphological, and thermal properties of nanofillers were investigated by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The analysis revealed that the particle size distribution was reduced from micro to nano size in the range of around 14 to 100 nm. Scanning electron microscopy (SEM) observations revealed that the nanoparticles of OPEFB had irregular shapes. The elemental composition of the OPEFB were investigated by elemental dispersive Xray analysis (EDX), showing the presence of tin, carbon, oxygen, chlorine, and bromine elements both before and after ball milling. Further, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) indicated that the developed nanofillers exhibited enhanced thermal properties compared to the untreated fibers. Such results suggest that the developed nano-filler can be used for the fabrication of nanocomposites with improved fire retardancy.

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PEGylation and preliminary biocompatibility evaluation of magnetite–silica nanocomposites obtained by high energy ball milling

Cited by 31 publications

References 54 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Odyssey of a cancer nanoparticle: From injection site to site of action

Preparation and Characterization of Fire Retardant Nano-Filler from Oil Palm Empty Fruit Bunch Fibers

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