PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study

Lahooti, Afsaneh; Sarkar, Saeed; Rad, Hamidreza Saligheh; Gholami, Abdollah; Nosrati, Sahar; Müller, Robert N.; Laurent, Sophie; Grüttner, Cordula; Geramifar, Parham; Yousefnia, Hassan; Mazidi, Mohammad; Shanehsazzadeh, Saeed

doi:10.1007/s10967-016-5058-0

Cited by 25 publications

(26 citation statements)

References 26 publications

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“…All experiments were performed in quadruplicate, and % cell viability was shown as a percent relative of untreated control cells. [62][63][64] As illustrated in Figure 8, the toxicity of the synthesized Fe 3 O 4 Au-NPs to the cells was found to be nonsignificant in higher concentrations up to 140.0 ppm and they were well tolerated by WEHI164 cells in the MTT assay.…”

Section: Cytotoxicity Assaymentioning

confidence: 94%

Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Rasouli¹,

Basirun²,

Rezayi³

et al. 2018

IJN

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IntroductionIn the present research, we report a quick and green synthesis of magnetite nanoparticles (Fe3O4-NPs) in aqueous solution using ferric and ferrous chloride, with different percentages of natural honey (0.5%, 1.0%, 3.0% and 5.0% w/v) as the precursors, stabilizer, reducing and capping agent, respectively. The effect of the stabilizer on the magnetic properties and size of Fe3O4-NPs was also studied.MethodsThe nanoparticles were characterized by X-ray diffraction (XRD) analysis, field emission scanning electron microscopy, energy dispersive X-ray fluorescence, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM) and Fourier transform infrared spectroscopy.ResultsThe XRD analysis indicated the presence of pure Fe3O4-NPs while the TEM images indicated that the Fe3O4-NPs are spherical with a diameter range between 3.21 and 2.22 nm. The VSM study demonstrated that the magnetic properties were enhanced with the decrease in the percentage of honey. In vitro viability evaluation of Fe3O4-NPs performed by using the MTT assay on the WEHI164 cells demonstrated no significant toxicity in higher concentration up to 140.0 ppm, which allows them to be used in some biological applications such as drug delivery.ConclusionThe presented synthesis method can be used for the controlled synthesis of Fe3O4-NPs, which could be found to be important in applications in biotechnology, biosensor and biomedicine, magnetic resonance imaging and catalysis.

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Section: Cytotoxicity Assaymentioning

confidence: 94%

Ultrasmall superparamagnetic Fe3O4 nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Rasouli¹,

Basirun²,

Rezayi³

et al. 2018

IJN

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“…[29][30][31] As shown in Figure 8, the synthesized Fe 3 O 4 /Au-NPs were found to be nonsignificant toxic to the cells in higher concentration up to 140.0 ppm which are used in the biological applications were well tolerated by WEHI164 cells in the MTT assay. Briefly, in 96 well plates, WEHI164 fibro sarcoma cells (1 × 10 4 cells/well) supplied from Institute Pastor, Iran, were seeded and incubated for 24 hours at 37°C in 5% CO 2 incubator.…”

Section: Mtt Assaymentioning

confidence: 94%

Facile and greener hydrothermal honey‐based synthesis of Fe₃O₄/Au core/shell nanoparticles for drug delivery applications

Rasouli

Basirun

Johan

et al. 2018

J of Cellular Biochemistry

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In the present research, we report a greener, faster, and low‐cost synthesis of gold‐coated iron oxide nanoparticles (Fe3O4/Au‐NPs) by different ratios (1:1, 2:1, and 3:1 molar ratio) of iron oxide and gold with natural honey (0.5% w/v) under hydrothermal conditions for 20 minutes. Honey was used as the reducing and stabilizing agent, respectively. The nanoparticles were characterized by X‐ray diffraction (XRD), UV‐visible spectroscopy, field emission scanning electron microscope (FESEM), energy‐dispersive X‐ray spectroscopy (EDXS), transmission electron microscopy (TEM), selected area electron diffraction (SAED), vibrating sample magnetometer (VSM), and fourier transformed infrared spectroscopy (FT‐IR). The XRD analysis indicated the presence of Fe3O4/Au‐NPs, while the TEM images showed the formation of Fe3O4/Au‐NPs with diameter range between 3.49 nm and 4.11 nm. The VSM study demonstrated that the magnetic properties were decreased in the Fe3O4/Au‐NPs compared with the Fe3O4‐NPs. The cytotoxicity threshold of Fe3O4/Au‐NPs in the WEHI164 cells was determined by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. It was demonstrated no significant toxicity in higher concentration up to 140.0 ppm which can become the main candidates for biological and biomedical applications, such as drug delivery.

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“…A variant of the iron oxide material platform, that is, iron oxyhydroxide or ferrihydrite nanoparticles functionalized with nicotinamide adenine dinucleotide (NAD) and glucosamine/gluconic acid, has also shown promise for tumour targeting by labelling with 99m Tc and 125 I 69 . In addition, the functionality of iron oxide nanoparticles can be enhanced by introducing 68 Ga or further PEGylation, which can be used for optical guidance in lymph node imaging 70,71 . In another seminal study, 89 Zr‐ferumoxytol‐desferrioxamine chelate radiolabelled iron oxide nanoparticles have shown appreciable potential for deep tissue lymphatic drainage imaging as an indicator of cancer prognosis and therapeutic monitoring 72 .…”

Section: Different Nanoparticle Systems Used For Delivery Of Radiophamentioning

confidence: 99%

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

Datta

Ray

2020

Labelled Comp Radiopharmac

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Application of nanotechnology principles in drug delivery has created opportunities for treatment of several diseases. Nanotechnology offers the advantage of overcoming the adverse biopharmaceutics or pharmacokinetic properties of drug molecules, to be determined by the transport properties of the particles themselves. Through the manipulation of size, shape, charge, and type of nanoparticle delivery system, variety of distribution profiles may be obtained. However, there still exists greater need to derive and standardize definitive structure property relationships for the distribution profiles of the delivery system. When applied to radiopharmaceuticals, the delivery systems assume greater significance. For the safety and efficacy of both diagnostics and therapeutic radiopharmaceuticals, selective localization in target tissue is even more important. At the same time, the synthesis and fabrication reactions of radiolabelled nanoparticles need to be completed in much shorter time. Moreover, the extensive understanding of the several interesting optical and magnetic properties of materials in nanoscale provides for achieving multiple objectives in nuclear medicine. This review discusses the various nanoparticle systems, which are applied for radionuclides and analyses the important bottlenecks that are required to be overcome for their more widespread clinical adaptation.

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PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study

Cited by 25 publications

References 26 publications

Ultrasmall superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Ultrasmall superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Facile and greener hydrothermal honey‐based synthesis of Fe₃O₄/Au core/shell nanoparticles for drug delivery applications

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

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PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study

Cited by 25 publications

References 26 publications

Ultrasmall superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Ultrasmall superparamagnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles: honey-based green and facile synthesis and in vitro viability assay

Facile and greener hydrothermal honey‐based synthesis of Fe3O4/Au core/shell nanoparticles for drug delivery applications

Nanoparticulate formulations of radiopharmaceuticals: Strategy to improve targeting and biodistribution properties

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Facile and greener hydrothermal honey‐based synthesis of Fe₃O₄/Au core/shell nanoparticles for drug delivery applications