Pegylated polyelectrolyte nanoparticles containing paclitaxel as a promising candidate for drug carriers for passive targeting

Szczepanowicz, Krzysztof; Bzowska, Monika; Kruk, Tomasz; Karabasz, Alicja; Bereta, Joanna; Warszyński, Piotr

doi:10.1016/j.colsurfb.2016.03.064

Cited by 41 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30,31 Moreover, when NCNLCs extravasated in the tumor tissues while prohibiting the carriers to exit the capillaries in normal tissues, an ideal targeting goal would be achieved. [32][33][34] And the NG encapsulated in NCNLCs can be accumulated efficiently in tumor sites because of the enhanced permeability and retention effect (EPR). 35 In addition, a narrow polydispersity index (0.29) indicated an acceptable preparation technology.…”

Section: Preparation and Characterization Of Ncnlcsmentioning

confidence: 99%

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

Zhu¹,

Huang²,

Zhang³

et al. 2020

DDDT

View full text Add to dashboard Cite

Background: "Unification of medicines and excipients" is the special principle which means fatty oil with pharmacodynamic activity derived from traditional Chinese medicine are taken as liquid lipids in perparation for dual-drug delivery, which improve the treatment effect and reduce unnecessary excipients. Purpose: The aim of this study was to prepare a nanostructured lipid carrier (NLC) with naringin (NG) containing coix seed oil (CSO) as liquid lipid based on the theory (NCNLC) in order to achieve synergistic antitumor activity against hepatocellular carcinoma. Methods: We developed NCNLCs using ultrasonic melt-emulsification method. The antitumor effect in vivo/in vitro and drug release ability were compared to NLC prepared with conventional liquid lipids: neodecanoate triglycerides (NDNLC) and oleic acid (NONLC). Results: Transmission electron microscopy showed that NCNLCs had a well-defined spherical shape, small size, and narrow polydispersity index. Importantly, the release of drugs from NDNLCs and NONLCs was slower than NCNLCs. In the cell study, the result showed a significantly greater antiproliferative effect towards HepG2 cells, and the half-maximal inhibitory concentration of NCNLCs was 3.24-fold, 1.70-fold and 1.52-fold lower to that of free drug, NDNLCs and NONLCs, respectively. Moreover, NCNLCs significantly induced HepG2 cells apoptosis by being 2.12-fold and 9.28-fold higher to that of NDNLCs and NONLCs, respectively. In the study of antitumor efficacy in vivo, the synergistic effect of NCNLCs formulation showed markedly enhanced antitumor efficacy in a xenograft model of liver cancer. Conclusion: The advantages of "unification of medicines and excipients" in formulation characters, drug release and synergistic antitumor effect provide a new idea for the application of the fatty oil of traditional Chinese medicine in the nano-drug delivery for cancer therapy.

show abstract

Section: Preparation and Characterization Of Ncnlcsmentioning

confidence: 99%

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

Zhu¹,

Huang²,

Zhang³

et al. 2020

DDDT

View full text Add to dashboard Cite

show abstract

“…Therefore, the present research aims to develop a novel biodegradable thiolated sodium alginate (TSA) derived nanospheres with modified surface to improve the delivery and release of paclitaxel (PCX) to the targeted site of colonic cancer cells. PCX was selected as an anticancer drug model because it can treat various types of cancers, including colon cancer [17,19].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible disulphide cross-linked sodium alginate derivative nanoparticles for oral colon-targeted drug delivery

Ayub

Chiu

Yusuf

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

The application of layer-by-layer (LbL) approach on nanoparticle surface coating improves the colonspecific drug delivery of insoluble drugs. Here, we aimed to formulate a self-assembled cysteaminebased disulphide cross-linked sodium alginate with LbL self-assembly to improve the delivery of paclitaxel (PCX) to colonic cancer cells. Cysteamine was conjugated to the backbone of oxidized SA to form a core of self-assembled disulphide cross-linked nanospheres. P3DL was selected for PCX loading and fabricated LbL with poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSCMA) resulting from characterization and drug release studies. P3DL-fabricated PCX-loaded nanospheres (P3DL/PAH/PSSCMA) exhibited an encapsulation efficiency of 77.1% with cumulative drug release of 45.1%. Dynamic light scattering analysis was reported at 173.6 ± 2.5 nm with polydispersity index of 0.394 ± 0.105 (zeta potential¼ À58.5 mV). P3DL/PAH/PSSCMA demonstrated a pH-dependent swelling transition; from pH 1 to 7 (102.2% increase). The size increased by 33.0% in reduction response study after incubating with 10 mM glutathione (day 7). HT-29 cells showed high viabilities (86.7%) after treatment with the fabricated nanospheres at 0.8 mg/mL. Cellular internalization was successful with more than 70.0% nanospheres detected in HT-29 cells. Therefore, this fabricated nanospheres may be considered as potential nanocarriers for colon cancer-targeted chemotherapeutic drug delivery. ARTICLE HISTORY

show abstract

“…Warszynski et al developed a methodology for producing microcapsules [42] and nanocapsules [43,44,45], which is based on emulsion drops that are covered by multilayered…”

Section: Introductionmentioning

confidence: 99%

“…The cargo is located in the disperse phase, i.e. in the droplets, which are stabilized against coalescence by appropriate amphiphilic molecules, which can be surfactants, polymers and proteins [40,41].Warszynski et al developed a methodology for producing microcapsules [42] and nanocapsules [43,44,45], which is based on emulsion drops that are covered by multilayered…”

mentioning

confidence: 99%

Encapsulation of oils and fragrances by core-in-shell structures from silica particles, polymers and surfactants: The brick-and-mortar concept

Radulova

Slavova

Kralchevsky

et al. 2018

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Colloidosomes provide a possibility to encapsulate oily substances in water in the form of core-in-shell structures. In this study, we produced microcapsules with shell from colloidal particles, where the interparticle openings are blocked by mixed layers from polymer and surfactant that prevent the leakage of cargo molecules. In other words, the particles and polymer play the role of bricks and mortar. For this goal, we used hydrophilic silica particles, which were partially hydrophobized by the adsorption of potassium oleate to enable them to stabilize Pickering emulsions. Various polymers were tested to select the most appropriate one. The procedure of encapsulation is simple and includes single homogenization by ultrasound. The produced capsules are pH responsive. They are stable in aqueous phase of pH in the range 3 -6, but at pH > 6 they are destabilized and their cargo is released. With the optimized formulation of silica particles, polymer, oleate and NaCl, we were able to encapsulate various oils and fragrances, such as tetradecane, limonene, benzyl salicylate and citronellol. All of them have a limited and not too high solubility in water. In contrast, no stable microcapsules were obtained with oils that either have zero water solubility (mineral and silicone oil) or higher water solubility (phenoxyethanol and benzyl alcohol). By analysis of results from additional interfacial-tension and thin-film experiments, we concluded that a key factor for obtaining stable capsules is the irreversible adsorption of the polymer at the oil/water interface. The hydrophobization of the particles by surfactant adsorption (instead of silanization) plays an important role for the pH responsiveness of the produced capsules. The obtained information about the role of various factors for the stabilization of microcapsules, which are based on the brick-and-mortar concept, can be further used to achieve better stability; selection of polymers that are appropriate for different classes of oils, as well as for the production of smaller capsules stabilized by nanoparticles. (P.A. Kralchevsky). Introduction.The development of micro-and nanocapsules with controlled composition and properties has been a subject of intensive research in the last decade. The stimuli responsive release of cargo molecules from the carrier gains a remarkable attention for in vivo and in vitro delivery of contrast agents, genes, and pharmaceuticals [1]. The colloidal capsules find another broad field of applications in house-hold and personal-care detergency, cosmetics and food industry, e.g. for the encapsulation of fragrances, flavors, colorants and preservatives [2,3].By their chemical nature, the colloidal carriers are classified as inorganic, organic and hybrid, e.g. mineralized protein capsules [1,4]. Different classes of colloidal carriers can be distinguished in relation to their structure and morphology: micelles; dendrimers; liposomes; niosomes; polymersomes; cubosomes and hexosomes; colloidosomes, and emulsion-based micro-and nanocapsules [1,5...

show abstract

Pegylated polyelectrolyte nanoparticles containing paclitaxel as a promising candidate for drug carriers for passive targeting

Cited by 41 publications

References 38 publications

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

<p>Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”</p>

Biocompatible disulphide cross-linked sodium alginate derivative nanoparticles for oral colon-targeted drug delivery

Encapsulation of oils and fragrances by core-in-shell structures from silica particles, polymers and surfactants: The brick-and-mortar concept

Contact Info

Product

Resources

About