Pegylated-polycaprolactone nano-sized drug delivery platforms loaded with biocompatible silver(i) complexes for anticancer therapeutics

Abstract

Cytotoxic potential of Ag(I) coordination compounds against cancer cells is widely recognized, but their frequently low water solubility and potential adverse interactions of Ag(I) ions in biological media require their...

Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications

“…Maximizing delivery, stealth and active targeting is the major focus of materials design in second-generation nanosystem design through primary functionalization (coating). 222 However, active targeting and selectivity are disappointing in second-generation functional strategies. As a result of the third generation, designers have shifted their focus from stable nanomaterials to “intelligent” environment-responsive systems that should allow for better release of targeted compounds, shown in Fig.…”