PEGylated Molybdenum–Iodine Nanocluster as a Promising Radiodynamic Agent against Prostatic Adenocarcinoma
Tomáš Přibyl,
Michaela Rumlová,
Romana Mikyšková
et al.
Abstract:The combination of photodynamic therapy and radiotherapy has given rise to a modality called radiodynamic therapy (RDT), based on reactive oxygen species-producing radiosensitizers. The production of singlet oxygen, O 2 ( 1 Δ g ), by octahedral molybdenum (Mo 6 ) clusters upon X-ray irradiation allows for simplification of the architecture of radiosensitizing systems. In this context, we prepared a radiosensitizing system using copper-free click chemistry between a Mo 6 cluster bearing azido ligands and the ho… Show more
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