PEGylated lipids impede the lateral diffusion of adsorbed proteins at the surface of (magneto)liposomes

Nuytten, Nele; Hakimhashemi, Maryam; Ysenbaert, T; Defour, Lien; Trekker, Jesse; Soenen, Stefaan J.; Meeren, Paul Van der; Cuyper, Marcel De

doi:10.1016/j.colsurfb.2010.06.009

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…3,4 Magnetoliposomes have been proposed as T2 contrast agents (negative contrast enhancement) in MRI, 5 while in therapy they have been used as a chemotherapy alternative through magnetic-controlled drug delivery and thermotherapy. [6][7][8] Considering the wide applications of magnetoliposomes, much attention has been paid to the synthesis of different kinds of magnetic nanoparticles 9-11 and liposomes. [12][13][14][15] Magnetoliposomes are specially promising as nanocarriers for potential antitumor drugs.…”

Section: Introductionmentioning

confidence: 99%

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies

et al. 2017

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Magnetoliposomes containing superparamagnetic manganese ferrite nanoparticles were tested as nanocarriers for two new promising antitumor drugs, a N-(3-methoxyphenyl)thieno[3,2-b]pyridin-7-amine (1) and a N-(2-methoxy-phenyl)thieno[3,2-b]pyridin-7-amine (2). The fluorescence emission of both compounds was studied in different polar and non-polar media, evidencing a strong intramolecular charge transfer character of the excited state of both compounds. These in vitro potent antitumor thienopyridine derivatives were successfully incorporated in both aqueous and solid magnetoliposomes, with encapsulation efficiencies higher than 75%. The magnetic properties of magnetoliposomes containing manganese ferrite nanoparticles were measured for the first time, proving a superparamagnetic behaviour. Growth inhibition assays on several human tumor cell lines showed very low GI 50 values for drug-loaded aqueous magnetoliposomes, comparing in most cell lines with the ones previously obtained using the neat compounds. These results are important for future drug delivery applications using magnetoliposomes in oncology, through a dual therapeutic approach (simultaneous chemotherapy and magnetic hyperthermia).

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Section: Introductionmentioning

confidence: 99%

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies

et al. 2017

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“…Moreover, liposomes revealed advantageous in overcoming issues of solubility, pharmacokinetics, toxicity and in vivo stability and toxicity of other delivery systems [9][10][11]. Magnetoliposomes have been used as a chemotherapy alternative through magnetically-controlled drug delivery and thermotherapy [12][13][14][15]. Iron oxide nanoparticles (Fe 3 O 4 , -Fe 2 O 3 ) have been widely used due to their proven biocompatibility and low toxicity [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

Rodrigues

Mendes

Silva

et al. 2017

Colloids and Surfaces B: Biointerfaces

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Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane. A promising application of these magnetoliposomes in oncology is anticipated, allowing a combined therapeutic approach, using both chemotherapy and magnetic hyperthermia.

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“…Liposomes entrapping magnetic nanoparticles (magnetoliposomes) are of large importance in drug delivery, as they can be guided and localized to the therapeutic site of interest by external magnetic field gradients and used in cancer treatment by hyperthermia [8,9]. In diagnosis, magnetoliposomes have been proposed as T2 contrast agents (negative contrast enhancement) in MRI [10], while in therapy they have been used as a chemotherapy alternative through magnetic-controlled drug delivery and thermotherapy [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Magnetoliposomes based on nickel/silica core/shell nanoparticles: Synthesis and characterization

Rodrigues

Gomes

Almeida

et al. 2014

Materials Chemistry and Physics

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PEGylated lipids impede the lateral diffusion of adsorbed proteins at the surface of (magneto)liposomes

Cited by 17 publications

References 29 publications

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies

Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies

Solid and aqueous magnetoliposomes as nanocarriers for a new potential drug active against breast cancer

Magnetoliposomes based on nickel/silica core/shell nanoparticles: Synthesis and characterization

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