PEGylated Interferon Displays Differences in Plasma Clearance and Bioavailability Between Male and Female Mice and Between Female Immunocompetent C57Bl/6J and Athymic Nude Mice

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

“…We show pkCSM achieved a performance as good as or better than similar methods currently available, presenting a significant improve in performance for 11 data sets (water solubility, Caco2 permeability, rat, Tetrahymena pyriformis, and minnow toxicity, P-glycoprotein inhibitors, and CYP450 1A2, C19, and 2C9 inhibitors). While chemical modifications and drug carriers can improve a compounds ADMET properties, − pkCSM provides a rapid and easy method to for early evaluation of compounds. In the Supporting Information, we apply these predictive models to understanding the pharmacokinetic and toxicity properties of diverse, challenging chemical sets, including macrocycles and antineoplastic drugs.…”

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

“…SEC-MALS analysis was performed to determine the molecular weight distribution and average molecular weight of PEGylated Enf as previously described [17,[19][20][21]. Peg-Enf (0.15 µg in 50 µl) was run on a Tosoh TSKgel SuperSW2000 4.6 X 300 mm column equilibrated in PBS at a flow rate of 0.35 ml/min using a Shimadzu LC-20AD isocratic HPLC coupled to a Dawn Heleos MALS detector and an Optilab T-rEX refractive index detector (Wyatt Technologies).…”