Pegylated Interferon and Ribavirin as an Available Variant of Antiviral Therapy for Chronic Hepatitis C in Hiv Infected

Азовцева, О. В.; Arhipov, G. S.; Trofimova, Tatiana

doi:10.22328/2077-9828-2017-9-3-39-46

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The object of the study was the substance of modified PEGylated interferon alfa-2b (Binnopharm JSC, Russia), which has improved biopharmaceutical characteristics compared to interferon alfa-2b, in particular, greater stability, shelf life, better permeability, and bioavailability [2,19]. Solid fats Witepsol® H15, Witepsol® W 35, Suppocire® BS2X and Suppocire® BM (EP 01/2009: 0462) were used as the basis for suppositories (table 1).…”

Section: Methodsmentioning

confidence: 99%

The Development and Study of the Toxicity of Suppositories With a Modified Substance of Interferon Alfa-2b

Анурова

E.O.²,

Shumkova³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: To develop a stable composition with the substance of PEGylated interferon alfa-2b, to study technological and biopharmaceutical characteristics of the dosage form, and to conduct preclinical studies on the chronic toxicity and local irritating effect. Methods: Solid fats Witepsol® H15, Witepsol® W 35, Suppocire® BS2X, and Suppocire® BM brands were used as the suppository bases. Polysorbate 80 was used as an emulsifier. Citric acid, ascorbic acid, sodium tetraborate, lactic acid, ethylenediaminetetetraacetic acid, tocopherol acetate was also introduced into the experimental samples. Fourteen experimental samples were screened for biological and technological indicators. Preclinical studies were performed for the optimal composition on the indicators of chronic toxicity and local irritant effect. Results: The study examined the cytotoxic effects on the Vero cell line of selected suppository bases and excipients, namely, pH regulators and antioxidants. With excipients that did not have cytotoxicity we obtained suppository compositions with the following quality indicators: cytotoxicity, specific activity of interferon, time of complete deformation of suppositories and their melting temperature. A total of 14 compositions were studied, of which 5 were selected on the basis of the results for the study of stability. Only one composition turned out to be stable for the time studied. Conclusion: The most stable in terms of “specific activity” was sample 7, its composition: Witepsol® H15/W35 70/30, polysorbate-80 0.15%, ethylenediaminetetraacetic acid (EDTA) 0.15%, sodium tetraborate 0.15%, tocopherol acetate 3.0%. Preclinical studies, that showed the absence of chronic toxicity and local irritant effect, were performed for this composition.

show abstract

Section: Methodsmentioning

confidence: 99%

The Development and Study of the Toxicity of Suppositories With a Modified Substance of Interferon Alfa-2b

Анурова

E.O.²,

Shumkova³

et al. 2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

Women Coinfected With Hiv and Vhc. Part 1. Psychosocial Characteristic and Readiness to Antiviral Therapy

Khalezova

Боева

Рассохин

et al. 2018

VIČ-infekc. immunosupr.

View full text Add to dashboard Cite

The objective of the present study was the analysis of medical and social status of women co-infected with HIV and VHC with the following assessment of their readiness to antiviral therapy of chronic hepatitis C virus infection (CHC) taking into account the mental health and living conditions and sustaining the adherence to antiviral therapy thereafter. Materials and methods. To clarify the social and psychological status, 100 outpatient cards of women co-infected with HIV/HCV were analyzed. The in-depth study with the assessment of the psychosocial and detoxification status and the adherence to antiretroviral therapy (ART) was held in fifty patients. Results. Most of the women had a long-standing history of HIV infection and HCV. Of these, 78% underwent ART and 84,6% had a high adherence to treatment. The main social problems of the women were connected with their work (34,2%) and family circumstances (26,3%). An increase in the concentration of carbohydrate-deficient transferrin (CDT), the marker of chronic alcohol abuse, was detected in three of 50 patients, and other three of the 50 had this parameter in the zone of unstable values. 72% of the patients showed mental disorders, while more than half of them (60%) had actively used psychoactive substances, and organic symptomatic mental disorder effects were observed in 20% of the patients. Most of the women were in remission on the use of psychoactive substances. Evaluation of the depression and anxiety levels has showed scattered results but in the meantime 54% of the women expressed complaints of asthenic nature, anxious mood was marked in 38% of the patients, 40% of them earlier had been suicidally inclined. Conclusion. Taking into account the social problems in one-third of patients that may negatively affect the treatment of HCV and HIV infection, it is essential to lend complimentary psychological support and assist with solving difficulties before the treatment assignment in order to increase the adherence to treatment. Due to mental health reasons, the patients need continuous observation and periodic condition correction. The majority of surveyed agree ART of CHC at this moment and in the short term but carefully relate to offered treatment regimens and its duration. Given the mental state of the patients, it can be assumed that virus C in women with HIV/HCV co-infection should be treated with direct-acting antiviral agents that do not exacerbate existing disorders. The next issue of the journal .HIV infection and immunosuppression disorders. (2018. Vol. 10, No. 4) will present the results of the study of clinical status features and the prospects for the therapy.

show abstract

Pegylated Interferon and Ribavirin as an Available Variant of Antiviral Therapy for Chronic Hepatitis C in Hiv Infected

Cited by 2 publications

References 0 publications

The Development and Study of the Toxicity of Suppositories With a Modified Substance of Interferon Alfa-2b

The Development and Study of the Toxicity of Suppositories With a Modified Substance of Interferon Alfa-2b

Women Coinfected With Hiv and Vhc. Part 1. Psychosocial Characteristic and Readiness to Antiviral Therapy

Contact Info

Product

Resources

About