PEGylated fullerene/iron oxide nanocomposites for photodynamic therapy, targeted drug delivery and MR imaging

Shi, Jinjin; Yu, Xiaoyuan; Wang, Lei; Liu, Yan; Gao, Jun; Zhang, Jing; Ma, Rou; Liu, Ruiyuan; Zhang, Zhenzhong

doi:10.1016/j.biomaterials.2013.08.049

Cited by 195 publications

(89 citation statements)

References 42 publications

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“…It is well known that the larger the PEG molecular weight, the longer the retention time of the TNE in vivo. The longer the retention time the higher the concentration of SRB-VE in tumor tissue [40][41][42][43]. We have therefore synthesized a larger molecular weight PEGylated VE, called VV2k.…”

Section: Ex Vivo Tissues and Live Animal Imaging Of Lctnementioning

confidence: 99%

Theranostic Nanoemulsions: Codelivery of Hydrophobic Drug and Hydrophilic Imaging Probe for Cancer Therapy and Imaging

Yang

Wang

et al. 2014

Nanomedicine (Lond.)

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Section: Ex Vivo Tissues and Live Animal Imaging Of Lctnementioning

confidence: 99%

Theranostic Nanoemulsions: Codelivery of Hydrophobic Drug and Hydrophilic Imaging Probe for Cancer Therapy and Imaging

Yang

Wang

et al. 2014

Nanomedicine (Lond.)

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“…15 Building upon previous reports that used Fe 3 O 4 (iron oxide) for magnetic targeted drug delivery and magnetic resonance imaging (MRI), 16 17 we showed that PEGylated fullerene/Fe 3 O 4 nanocomposites can be used as drug delivery vectors and T 2 -contrast agents for MRI. 18 Upon intravenous administration, magnetic carriers can be concentrated at tumor sites using an external high gradient magnetic field, 19 20 where they release drugs that are then taken up by tumor cells. Therefore, in this study, Fe 3 O 4 was linked to multiwalled carbon nanotubes (MWNTs) to allow both magnetic targeting and diagnosis by MRI.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Multi-Walled Carbon Nanotubes for Tumor Theranostics

Wang¹,

Shi²,

Hao³

et al. 2015

j biomed nanotechnol

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Current diagnostic techniques do not reliably detect cancer at early stages, and traditional chemotherapy lacks specificity and causes systemic toxicity. To address these issues, multifunctional nanomaterials are becoming more widely studied as a means of cancer detection, therapy, and monitoring. Here, iron oxide (Fe3O4) nanoparticles were conjugated onto the surface of multi-walled carbon nanotubes (MWNTs), which were then modified with polyethylenimine (PEI) and polyethylene glycol (PEG) to improve their solubility and biocompatibility. Finally, human telomerase reverse transcriptase (hTERT) siRNA was loaded on the MWNT surface by electrostatic interaction to obtain a multifunctional delivery system (MWNT-Fe3O4-PEI-PEG/siRNA). This delivery system efficiently delivered siRNA, allowed targeting of certain sites by magnetic fields, facilitated photothermal heating by near infrared irradiation, and enabled magnetic resonance imaging, thereby indicating great potential for cancer theranostic applications.

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“…Since C 60 ± IONP ± PEG can be further used as a T 2 -contrast agent for in vivo MRI, it was concluded that the C 60 ± IONP ± PEG/HMME system has a great potential for cancer theranostic applications. 330 It is the impression that EMFs were designed by nature as a basis for contrast agents. In these molecules, the carbon cage protects a metal atom (or a group of atoms) from the external environment.…”

Section: Iii3 Biomedical Applicationsmentioning

confidence: 99%