PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma

Wang, Yue; Wan, Guoyun; Li, Zhiyuan; Shi, Shurui; Chen, Bo-Wei; Li, Chunyu; Zhang, Lianyun; Wang, Yinsong

doi:10.1016/j.ijpharm.2017.04.027

Cited by 21 publications

(15 citation statements)

References 28 publications

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“…Electrostatic interactions can mediate the form of multilayer NPs to deliver Sraf (an inhibitor of tyrosine kinases), exhibiting superior anticancer activities than free Sraf in the oral cancer cells [117]. Ligand-decorated NPs can specifically bind to and be efficiently internalized in receptor-overexpressed OSCC cancer cells [118,119]. Besides, polyelectrolyte-assembling multilayer NPs (MLNPs) have been developed as a drug delivery system encapsulated with multiple drugs, such as cisplatin and chrysin.…”

Section: Polymeric Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate. Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal. Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer. Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices. Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect. In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers. Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented. The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

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Section: Polymeric Nanoparticles For Oral Cancer Diagnosis and Therapymentioning

confidence: 99%

Nanoparticles for Oral Cancer Diagnosis and Therapy

Zheng

Zhou

Yuan

2021

Bioinorganic Chemistry and Applications

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“…Collectively, HNPD NPs can target tumor cells, exert good in vivo and in vitro therapeutic effects, and are simple to prepare. Hence, these novel nanoplatforms show potential for application in clinical practice (Wang et al, 2017).…”

Section: Research Progress In Nanoplatforms For the Treatment Of Oralmentioning

confidence: 99%

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

Zhao

et al. 2020

Front. Pharmacol.

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Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral cancer include surgery, radiation therapy, and chemotherapy. However, these methods have many disadvantages. In recent years, nanomedicine, the delivery of drugs through nanoplatforms for the treatment of cancer, has become a promising substitutive therapy. The use of nanoplatforms can reduce the degradation of the drug in the body and accurately deliver it to the tumor site. This minimizes the distribution of the drug to other organs, thereby reducing its toxicity and allowing higher drug concentration at the tumor site. This review introduces polymer nanoparticles, lipid-based nanoparticles, metal nanoparticles, hydrogels, exosomes, and dendrimers for the treatment of oral cancer, and discusses how these nanoplatforms play an anti-cancer effect. Finally, the review gives a slight outlook on the future prospects of nanoplatforms for oral cancer treatment.

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“…Doxorubicin (DOX) and paclitaxel are two of the most commonly used chemotherapeutic drugs [ 239 ]. Taking their adverse effects into consideration, studies have proposed alternative forms of drug delivery, such as liposome formulations [ 239 ], solid lipid NPs [ 240 ], mucoadhesive alginate pastes with embedded liposomes [ 241 ], methotrexate-loaded stimuli responsive silica-based NPs [ 242 ], polymers [ 243 ], PEGylated NPs [ 244 , 245 ], mesoporous silica NPs-polymerpolyethylenimine [ 246 ], multifunctional targeted polymeric NPs [ 247 ], and a multifunctional Au nanoplatform [ 248 ]. In comparison to the free drugs, these new systems showed a higher percentage of apoptotic cells [ 239 , 247 ], fewer hematological changes [ 242 ], significant therapeutic efficacy [ 243 , 248 ], significant inhibitory effects on tumor growth [ 245 ], lower cytotoxicity and systemic toxicity, and higher tumor accumulation of DOX [ 244 ].…”

Section: Head Neck and Oral Cancermentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma

Cited by 21 publications

References 28 publications

Nanoparticles for Oral Cancer Diagnosis and Therapy

Nanoparticles for Oral Cancer Diagnosis and Therapy

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

Nanoparticles in Dentistry: A Comprehensive Review

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