PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications

Casettari, Luca; Vllasaliu, Driton; Castagnino, Enzo; Stolnik, Snow; Howdle, Steven M.; Illum, Lisbeth

doi:10.1016/j.progpolymsci.2011.10.001

Cited by 208 publications

(109 citation statements)

References 227 publications

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“…We focused on chitosan derivatives, which are known to promote wound healing. Other chitosan derivatives developed for other purposes have also been described in literature in the context of wound healing (Alves & Mano, 2008;Casettari et al, 2012;Francesko & Tzanov, 2011;Park et al, 2010). Specifically, for diabetic wounds, where healing fails, other chitosan derivatives have been proposed (Moura et al 2013) to increase fibroblast migration and collagen deposition in diabetic mice (Moura et al 2014).…”

Section: Figure 1 Wound Classification (Kyriacos Et Al 2008)mentioning

confidence: 99%

“…Depending on the proposed goals (e.g., increased solubility, cellular uptake, cell targeting ability), a large family of chitosan derivatives may be produced through chemical modifications, as reviewed elsewhere (Casettari et al, 2012;Kean & Thanou, 2010). Since chitosan application is limited by its poor solubility at physiological pH (Sieval et al, 1998), we will focus on water-soluble chitosan derivatives and their application in wound healing, specifically tri-methyl chitosan (TMC), carboxymethylchitosan (CMC) and carboxymethyl-trimethyl-chitosan (CMTMC).…”

Section: Chitosan Derivatives For Wound Healingmentioning

confidence: 99%

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Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

441

215

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Figure 1 Wound Classification (Kyriacos Et Al 2008)mentioning

confidence: 99%

Section: Chitosan Derivatives For Wound Healingmentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

441

215

View full text Add to dashboard Cite

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“…Neutralization of chitosan solutions with a strong base up to pH46.2 instantly leads to the formation of a hydrated gel-like precipitate. The positive charges of the chitosan amine groups are neutralized at this point and their repulsion eliminated, which results in the formation of chitosan-chitosan hydrogen bonds via its hydroxyl (-OH), amine (-NH 2 ), amide (-NH-C) and carbonyl (-C ¼ O) groups (Casettari et al, 2012).…”

Section: Thermosensitivity Of Cs/b-gp Solutionsmentioning

confidence: 99%

“…Chitosan consists of b-(1,4)-linked D-glucosamine units with variable degrees of N-acetylation (Casettari et al, 2012). It has been used for tissue regeneration (Ma et al, 2010;Cooper et al, 2011;Park et al, 2013) and drug delivery applications (Rokhade et al, 2007;Abruzzo et al, 2012;Ferrari et al, 2013) because of its tissue compatibility, biodegradability and low toxicity (Ao et al, 2011;Cooper et al, 2011;Tsai et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Tahrir¹,

Ganji²,

Mani

et al. 2014

Drug Delivery

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Injectable In situ gel-forming chitosan/b-glycerol phosphate (CS/b-Gp) solution can be introduced into the body in a minimally invasive manner prior to solidifying within the target tissue. This hydrogel is a good candidate for achieving a prolonged drug delivery system for insulin considering its high molecular weight. In addition to the physicochemical characterization of this hydrogel, in vitro and in vivo applications were studied as a sustained insulin delivery system. In the in vitro release studies, 19-63% of total insulin was released from the CS/b-Gp hydrogel within 150 h at different b-Gp and insulin concentrations. The best formulation was selected for in vivo experimentation to control the plasma glucose of diabetic mice models. The hypoglycemic effect of this formulation following subcutaneous injection in diabetic mice lasted 5 d, significantly longer than that of free insulin solution which lasted several hours.

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“…After the storage period of 3 months amorphous state of the polymeric structure remained unchanged showing that the particles were not affected from the storage conditions (Figure 2b). 52 XRD is one of the most important characterization tools used in solid state chemistry and materials science for the determination of the size and the shape of the unit cell for polycrystals in nanoscale. 53,54 Diffraction pattern gives information of the crystalline/amorphous structure of the materials.…”

Section: Resultsmentioning

confidence: 99%

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

Başaran¹

2017

tjps

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ÖZAmaç: Özellikle gözyaşı üretimi ve kırpma refleksleri gibi gözün koruyucu mekanizmalarına bağlı olarak göze topik olarak uygulanan formülasyonların göz yüzeyinden hızla uzaklaştırılması ve korneal yüzeyden verimsiz absorbsiyonu söz konusu olmaktadır. Prekorneal tutunma süresinin ve korneal permeabilitenin arttırılması ile oküler biyoyararlanımın arttırılmasında kolloidal ilaç taşıyıcı sistemler büyük önem taşımaktadır. Bu çalışmada antibakteriyel etkili bir madde olan diritromisin yüklü Kollidon ® SR yapılı polimerik nanopartiküller şiddetli oküler bakteriyel enfeksiyonların etkin tedavisi amacı ile hazırlanmıştır. Gereç ve Yöntemler: Bu çalışmada diritromisin Kollidon ® SR yapılı polimerik nanopartiküllere püskürterek kurutma yöntemi ile yüklenmiştir. Nanopartiküllerin in vitro karakteristik özellikleri üç farklı ortamda üç ay süresince detaylı olarak incelenmiştir. Bulgular: İn vitro analiz sonuçları parçacıkların üç aylık saklama süresince karakteristik özelliklerini koruduklarını göstermiştir. Sonuç: Kollidon ® SR yapılı polimerik nanopartiküllerin şiddetli oküler bakteriyel enfeksiyonların diritromisin ile tedavisinde oldukça etkili ilaç taşıyıcı sistem adayları olduklarını göstermiştir. Anahtar kelimeler: Diritromisin, Kollidon ® SR, polimerik nanopartiküller, oküler ilaç taşıyıcı sistemler Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon ® SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections. Materials and Methods: In this study, dirithromycin was incorporated into the Kollidon ® SR-based nanoparticles by spray drying method. In vitro characteristic properties were evaluated in detail during the storage period of three months at three different conditions. Results: The results of in vitro analyses revealed that characteristic properties of the particles were remained unchanged during the storage period of three months. Conclusion: Kollidon ® SR-based polymeric nanoparticles are good candidates for drug delivery systems in the treatment of severe ocular bacterial infections with dirithromycin.

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PEGylated chitosan derivatives: Synthesis, characterizations and pharmaceutical applications

Cited by 208 publications

References 227 publications

Chitosan as a starting material for wound healing applications

Chitosan as a starting material for wound healing applications

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an <i>In Vitro</i> Evaluation

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