PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling

Huang, Liwen; Zhang, Xiao; Ding, Zhaowen; Qi, Yilin; Wang, Wenjing; Xu, Xihan; Yue, Hua; Bai, Lihuan; Wang, Heping; Feng, Leyan; Ren, Jing; Yang, Xue; Ma, Guanghui; Wei, Wei; Xue, Xue

doi:10.1016/j.nantod.2022.101556

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Huang et al found that PEGylated graphene oxide could cause a flip-flop orientation shift of phosphatidylinositol-4,5-bisphosphate lipid within the membrane, which restricted the hydrolysis site to prevent cleavage-mediated inositol 1,4,5-trisphosphate (Fig. 2 A, B) [ 99 ]. This nano-bio interfacial effect reduced Ca 2+ -related endoplasmic reticulum stress to protect the neurons of Parkinson's disease mice (Fig.…”

Section: Effects Of Nano-bio Interfacial Interactions By 2d Nmsmentioning

confidence: 99%

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Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

Wang,

Zhang,

Yue

2024

J Nanobiotechnol

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Two-dimensional nanomaterials (2D NMs), characterized by a large number of atoms or molecules arranged in one dimension (typically thickness) while having tiny dimensions in the other two dimensions, have emerged as a pivotal class of materials with unique properties. Their flat and sheet-like structure imparts distinctive physical, chemical, and electronic attributes, which offers several advantages in biomedical applications, including enhanced surface area for efficient drug loading, surface-exposed atoms allowing precise chemical modifications, and the ability to form hierarchical multilayer structures for synergistic functionality. Exploring their nano-bio interfacial interactions with biological components holds significant importance in comprehensively and systematically guiding safe applications. However, the current lack of in-depth analysis and comprehensive understanding of interfacial effects on cancer treatment motivates our ongoing efforts in this field. This study provides a comprehensive survey of recent advances in utilizing 2D NMs for cancer treatment. It offers insights into the structural characteristics, synthesis methods, and surface modifications of diverse 2D NMs. The investigation further delves into the formation of nano-bio interfaces during their in vivo utilization. Notably, the study discusses a wide array of biomedical applications in cancer treatment. With their potential to revolutionize therapeutic strategies and outcomes, 2D NMs are poised at the forefront of cancer treatment, holding the promise of transformative advancements. Graphical Abstract

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Section: Effects Of Nano-bio Interfacial Interactions By 2d Nmsmentioning

confidence: 99%

Section: Effects Of Nano-bio Interfacial Interactions By 2d Nmsmentioning

confidence: 99%

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

Wang,

Zhang,

Yue

2024

J Nanobiotechnol

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“…In addition, researchers are constantly discovering unique biological functions of nanomaterials beyond their role as drug carriers. For example, black phosphorus (BP)‐based materials are now known to have antioxidant effects, [18] and polyethylene glycol‐modified graphene oxide exerts neuroprotective effects by regulating the PIP2‐endoplasmic reticulum (ER) stress pathway [19] . These biological functions can be leveraged for synergistic AD treatment using nanomaterial–drug combinations.…”

Section: Introductionmentioning

confidence: 99%

“…For example, black phosphorus (BP)-based materials are now known to have antioxidant effects, [18] and polyethylene glycol-modified graphene oxide exerts neuroprotective effects by regulating the PIP2endoplasmic reticulum (ER) stress pathway. [19] These biological functions can be leveraged for synergistic AD treatment using nanomaterial-drug combinations. Additionally, most nanomaterials are highly editable and can be modified for targeted action through membrane coating, chemical coupling, and other strategies, enabling targeted delivery and ensuring biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

Cheng

Xie

Zhao

et al. 2023

Brain-X

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Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Because of the complex pathogenesis of AD and the unique location of AD lesions, effective clinical treatment strategies for this disease remain elusive. However, the development of nanotechnology has allowed a new era of AD treatment to emerge. AD nanomedicines are products of interdisciplinary research that enable high precision and targeted delivery. Additionally, they can specifically regulate various pathogenic factors. This review focuses on nanomedicines based on the pathological mechanisms of AD that can target AD lesions. We also discuss the precise regulatory effects of nanomedicines (including the nanomaterials themselves) on pathogenic proteins, neuroinflammatory molecules, and other pathogenic factors. We summarize the clinical trials that have examined new AD drugs, highlighting the development of new nanomedicines and the progress in their clinical translation. Nanotechnology‐based AD treatment is a nascent field, and a complete cure is distant at present; therefore, we also elaborate on the shortcomings of current AD nanomedicines. Finally, we discuss the prospects to guide the future development of AD nanomedicines.

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Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms

et al. 2023

Advanced Science

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Engineering advanced therapeutic and diagnostic nano‐bio‐platforms (NBPFs) have emerged as rapidly‐developed pathways against a wide range of challenges in antitumor, antipathogen, tissue regeneration, bioimaging, and biosensing applications. Emerged 2D materials have attracted extensive scientific interest as fundamental building blocks or nanostructures among material scientists, chemists, biologists, and doctors due to their advantageous physicochemical and biological properties. This timely review provides a comprehensive summary of creating advanced NBPFs via emerging 2D materials (2D‐NBPFs) with unique insights into the corresponding molecularly restructured microenvironments and biofunctionalities. First, it is focused on an up‐to‐date overview of the synthetic strategies for designing 2D‐NBPFs with a cross‐comparison of their advantages and disadvantages. After that, the recent key achievements are summarized in tuning the biofunctionalities of 2D‐NBPFs via molecularly programmed microenvironments, including physiological stability, biocompatibility, bio‐adhesiveness, specific binding to pathogens, broad‐spectrum pathogen inhibitors, stimuli‐responsive systems, and enzyme‐mimetics. Moreover, the representative therapeutic and diagnostic applications of 2D‐NBPFs are also discussed with detailed disclosure of their critical design principles and parameters. Finally, current challenges and future research directions are also discussed. Overall, this review will provide cutting‐edge and multidisciplinary guidance for accelerating future developments and therapeutic/diagnostic applications of 2D‐NBPFs.

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PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling

Cited by 7 publications

References 48 publications

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms

Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano‐Bio‐Platforms

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