Pegfilgrastim Prophylaxis for Cladribine-Induced Neutropenia in Patients with Hairy-Cell Leukemia

Goldschmidt, Neta; Ganzel, Chezi; Attias, Dina; Gatt, Moshe E.; Polliack, Aaron; Tadmor, Tamar

doi:10.1159/000358293

Cited by 3 publications

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“…On the other hand, the administration of G-CSF in association with IFN-α in patients with HCL has been reported as a useful tool for managing or preventing neutropenic complications in the early phase of treatment [ 22 ]. In addition, a few studies have examined the effect of G-CSF [ 23 ], GM-CSF [ 24 ], and Pegfilgrastim [ 25 ] in reducing PNA treatment toxicity in patients with HCL.…”

Section: Discussionmentioning

confidence: 99%

Prompt Hematological Recovery in Response to a Combination of Pegylated Interferon α-2a and Rituximab in a Profoundly Immuno-Suppressed Hairy Cell Leukemia Patient with a Mycobacterial Infection at Onset: Benefits and Drawbacks of Rapid Immune Reconstitution

et al. 2022

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The present paper reports, to the best of our knowledge for the first time, the efficacy and tolerability of the combination of interferon (IFN)α-2a in pegylated formulation and rituximab after a “priming” phase with IFN in the frontline treatment of hairy cell leukemia (HCL) in a profoundly immunosuppressed patient with a Mycobacterium abscessus infection at onset. This immunotherapy combination may represent a potential therapeutic option in patients with active severe infection and for whom the use of purine nucleoside analogues (PNA) is contraindicated. The benefits and drawbacks of remarkably rapid immune reconstitution in the context of opportunistic infections are highlighted as well, as the potentially paradoxical effects of immune recovery as a result of effective immunotherapy strategies, known as immune reconstitution inflammatory syndrome (IRIS), have to be taken into account when dealing with patients with opportunistic infections.

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